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Proceedings Paper

Carrier systems in PDT II: accumulation strategies of biotin-avidin coupled photosensitizers developed on cultured tumor cells
Author(s): Anja Ruebner-Heuermann; Joerg G. Moser; Alexander P. Savitzki; D. Berendij; Rainer Bayer; Birgit Wagner
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Paper Abstract

Two possibilities to accumulate photosensitizing drugs at the surface of cultured tumor cells were exploited: biotinylation of the cell surface followed by avidin and dibiotin, and reaction with a biotinylated antibody followed by avidin and biotinylated sulfophthalocyanin. Both reactions were performed successfully. The latter leads to enhanced phototoxicity of the accumulated drug.

Paper Details

Date Published: 31 January 1996
PDF: 5 pages
Proc. SPIE 2625, Photochemotherapy: Photodynamic Therapy and Other Modalities, (31 January 1996); doi: 10.1117/12.230957
Show Author Affiliations
Anja Ruebner-Heuermann, Univ. Duesseldorf (Germany)
Joerg G. Moser, Univ. Duesseldorf (Germany)
Alexander P. Savitzki, Molecular Immunology Lab. (Russia)
D. Berendij, Univ. Duesseldorf (Germany)
Rainer Bayer, Univ. Duesseldorf (Germany)
Birgit Wagner, Univ. Duesseldorf (Germany)

Published in SPIE Proceedings Vol. 2625:
Photochemotherapy: Photodynamic Therapy and Other Modalities
Benjamin Ehrenberg; Giulio Jori; Johan Moan, Editor(s)

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