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Proceedings Paper

Monofunctional phthalocyanine derivatives as potential sensitizers for PDT
Author(s): Dieter Wohrle; Andrea Weitemeyer; Abdol Khezer Sobbi; Ulrike Michelsen; H. Kliesch
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Paper Abstract

Syntheses, singlet oxygen 1O2 quantum yields ((Phi) (Delta )) and photostability of new monofunctional, long wavelength absorbing (680 - 750 nm) porphyrazines are reported. For the coupling to biomolecules without crosslinking reactions the sensitizers contain one reactive polar sulfo, carboxy, amino, hydroxy, or pyridyloxy group. Besides, the sensitizers are substituted by lipophilic tert-butyl, tert-butylphenoxy or alkoxy groups in order to introduce an intramolecular polarity axis for better cellular uptake and to increase solubility in organic solvents.

Paper Details

Date Published: 31 January 1996
PDF: 9 pages
Proc. SPIE 2625, Photochemotherapy: Photodynamic Therapy and Other Modalities, (31 January 1996); doi: 10.1117/12.230956
Show Author Affiliations
Dieter Wohrle, Univ. Bremen (Germany)
Andrea Weitemeyer, Univ. Bremen (Germany)
Abdol Khezer Sobbi, Univ. Bremen (Germany)
Ulrike Michelsen, Univ. Bremen (Germany)
H. Kliesch, Univ. Bremen (Germany)


Published in SPIE Proceedings Vol. 2625:
Photochemotherapy: Photodynamic Therapy and Other Modalities
Benjamin Ehrenberg; Giulio Jori; Johan Moan, Editor(s)

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