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Proceedings Paper

Benzoporphyrins as photosenitizers for the photodynamic therapy of cancer
Author(s): Maria Asuncion Valles; Roberta Biolo; Raymond Bonnett; Magdalena Canete; Antonia Ma. Gomez; Giulio Jori; Angeles Juarranz; Kimberly A. McManus; Kawulia T. Okolo; M. Soncin; Angeles Villanueva
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Paper Abstract

A family of benzoporphyrins formed by differently substituted metallo tetrabenzoporphyrins and one opp-dibenzoporphyrin has been prepared. The former benzoporphyrins, and meso- tetra(m-hydroxy-phenyl)chlorin (m-THPC) to act as reference, have been encapsulated into liposomes and subjected to preliminary in vitro and in vivo assays to test their efficacy as photosensitizers in the photodynamic therapy of cancer. The results of the photocytotoxicity test shows that, with the exception of the nickel complexes 5, and 7/8, the other porphyrins are photobiologically active, the Mg-tetrabenzoporphyrin 1 and the opp-dibenzoporphyrin 10 being the most active. The dark toxicity of the photoactive porphyrins is in the range described for many photosensitizers, including HPD. The in vivo assays show no toxicity in the liver for any of the compounds tested, and also that 2 is the most promising photosensitizer among them, because of an efficient localization in an experimental mouse tumor.

Paper Details

Date Published: 31 January 1996
PDF: 12 pages
Proc. SPIE 2625, Photochemotherapy: Photodynamic Therapy and Other Modalities, (31 January 1996); doi: 10.1117/12.230955
Show Author Affiliations
Maria Asuncion Valles, Univ. de Barcelona (Spain)
Roberta Biolo, Univ. di Padova (Italy)
Raymond Bonnett, Queen Mary and Westfield College (United Kingdom)
Magdalena Canete, Univ. Autonoma de Madrid (Spain)
Antonia Ma. Gomez, Univ. de Barcelona (Spain)
Giulio Jori, Univ. degli Studi di Padova (Italy)
Angeles Juarranz, Univ. Autonoma de Madrid (Spain)
Kimberly A. McManus, Queen Marry and Westfield College (United Kingdom)
Kawulia T. Okolo, Queen Marry and Westfield College (United Kingdom)
M. Soncin, Univ. di Padova (Spain)
Angeles Villanueva, Univ. Autonoma de Madrid (Spain)

Published in SPIE Proceedings Vol. 2625:
Photochemotherapy: Photodynamic Therapy and Other Modalities
Benjamin Ehrenberg; Giulio Jori; Johan Moan, Editor(s)

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