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Highlighting the nuances behind interaction of picosecond pulses with human skin: Relating distinct laser-tissue interactions to their potential in cutaneous interventions
Author(s): Natallia E. Uzunbajakava; Babu Varghese; Natalia V. Botchkareva; Rieko Verhagen; Alfred Vogel
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Paper Abstract

In recent years, several commercial systems relying on picosecond pulses have been introduced into the field of cutaneous interventions. In parallel with this development, a somewhat distinct research prototype also operating in the picosecond regime was described in literature. Albeit both market-available products and the investigational device employ laser beams of nearly the same pulse duration and were reported to cause laser-induced optical breakdown (LIOB), they are different in terms of wavelength, applied fluence, laser beam quality, optical architecture and related focusing optics, resulting in different histomorphological features (such as e.g. lesion size, location, expression of collagen). Understanding the differences between these systems in relation to implications for clinical results raises a need in highlighting the nuances behind interaction of picosecond pulses with biological tissue. To achieve this, we accentuate the interplay of irradiance levels of picosecond pulses in W/cm2 , absorption properties of a target tissue at a wavelength of a light source and resulting interaction mechanisms with biological object. We also relate these nuances to potential consequences for cutaneous interventions.

Paper Details

Date Published: 20 February 2018
PDF: 11 pages
Proc. SPIE 10492, Optical Interactions with Tissue and Cells XXIX, 1049206 (20 February 2018); doi: 10.1117/12.2307804
Show Author Affiliations
Natallia E. Uzunbajakava, Philips Research (Netherlands)
Babu Varghese, Philips Research (Netherlands)
Natalia V. Botchkareva, Univ. of Bradford (United Kingdom)
Rieko Verhagen, Philips Research (Netherlands)
Alfred Vogel, Univ. zu Lübeck (Germany)


Published in SPIE Proceedings Vol. 10492:
Optical Interactions with Tissue and Cells XXIX
E. Duco Jansen; Hope Thomas Beier, Editor(s)

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