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Proceedings Paper

Blue LED treatment of superficial abrasions: in vivo experimental evidence of wound healing improvement
Author(s): Giada Magni; Francesca Tatini; Lucia Cavigli; Roberto Pini; Riccardo Cicchi; Stefano Bacci; Gaia Paroli; Gaetano DeSiena; Domenico Alfieri; Cristina Tripodi; Lorenzo Targetti; Francesco S. Pavone; Francesca Rossi
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Paper Abstract

After irradiation with a blue LED light photocoagulator, a faster healing process is observed in superficial skin wounds. This device has been used in order to induce a thermal effect and haemostasis in superficial abrasions. Our previous in vivo study in rat and mouse models focused on the inflammatory phase within the healing process, showed a light-induced modulation, which leads to a shortened healing time and to a better recovery of the dermal tissue. Here we describe a new series of experiments that have been conducted producing two superficial abrasions on the shaved-back of mice, treating the one wound with the blue light and leaving the other one healing without any treatment. The healthy skin was used as a control. The animals were observed during healing and sacrificed at different and selected time points. Wound tissue samples have been harvested both from the treated and untreated areas and examined by histopathological and immunofluorescence analysis, SHG imaging, and confocal microscopy. The results of the study point out the interaction among different cells type and the collagen morphology restoration as obtained in different pathological mice models treated with blue LED light.

Paper Details

Date Published: 17 May 2018
PDF: 6 pages
Proc. SPIE 10685, Biophotonics: Photonic Solutions for Better Health Care VI, 106850G (17 May 2018); doi: 10.1117/12.2307397
Show Author Affiliations
Giada Magni, Istituto di Fisica Applicata "Nello Carrara" (Italy)
Francesca Tatini, Istituto di Fisica Applicata "Nello Carrara" (Italy)
Lucia Cavigli, Istituto di Fisica Applicata "Nello Carrara" (Italy)
Roberto Pini, Istituto di Fisica Applicata "Nello Carrara" (Italy)
Riccardo Cicchi, Istituto Nazionale di Ottica (Italy)
LENS - Lab. Europeo di Spettroscopie Non-Lineari (Italy)
Stefano Bacci, Univ. degli Studi di Firenze (Italy)
Gaia Paroli, Univ. degli Studi di Firenze (Italy)
Gaetano DeSiena, Istituto di Fisica Applicata "Nello Carrara" (Italy)
Domenico Alfieri, EmoLED S.r.l. (Italy)
Cristina Tripodi, EmoLED S.r.l. (Italy)
Lorenzo Targetti, EmoLED S.r.l. (Italy)
Francesco S. Pavone, Istituto Nazionale di Ottica (Italy)
LENS - Lab. Europeo di Spettroscopie Non-Lineari (Italy)
Univ. degli Studi di Firenze (Italy)
Francesca Rossi, Istituto di Fisica Applicata "Nello Carrara" (Italy)


Published in SPIE Proceedings Vol. 10685:
Biophotonics: Photonic Solutions for Better Health Care VI
Jürgen Popp; Valery V. Tuchin; Francesco Saverio Pavone, Editor(s)

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