Share Email Print
cover

Proceedings Paper • new

Time-resolved single photon spectroscopy through a single optical fibre for miniaturised medical probe design
Author(s): K. Ehrlich; H. Fleming; S. McAughtrie; A. Kufcsák; N. Krstajić; C. J. Campbell; R. K. Henderson; K. Dhaliwal; R. R. Thomson; M. G. Tanner
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

We present a spectroscopic system and an optical fibre probe which enable the full exploitation of the temporal evolution and spectral information of a weak Raman signal against background fluorescence and intrinsic fibre Raman. The system consists of a single multimode fibre and a CMOS single-photon avalanche diode (SPAD) line sensor capable of resolving and histogramming the arrival times of photons for 256 pixels simultaneously, offering improved signal to background compared to a non-time resolved measurement modality. The capabilities of the system are tested for intrinsic Raman standards such as cyclohexane and for pH sensing with functionalised gold nanoshells exploiting surface enhanced Raman scattering (SERS). The nanoshells are functionalised with the pH responsive 4-mercaptobenzoic acid (MBA) enabling demonstration of wide range pH sensing with low excitation power (< 1 mW) and short acquisition times (10 s), achieving a measurement precision of ± 0.07 pH units.

Paper Details

Date Published: 17 May 2018
PDF: 7 pages
Proc. SPIE 10685, Biophotonics: Photonic Solutions for Better Health Care VI, 106850Q (17 May 2018); doi: 10.1117/12.2307334
Show Author Affiliations
K. Ehrlich, Heriot-Watt Univ. (United Kingdom)
The Univ. of Edinburgh (United Kingdom)
H. Fleming, The Univ. of Edinburgh (United Kingdom)
S. McAughtrie, The Univ. of Edinburgh (United Kingdom)

A. Kufcsák, The Univ. of Edinburgh (United Kingdom)
N. Krstajić, The Univ. of Edinburgh (United Kingdom)
C. J. Campbell, The Univ. of Edinburgh (United Kingdom)
R. K. Henderson, The Univ. of Edinburgh (United Kingdom)
K. Dhaliwal, The Univ. of Edinburgh (United Kingdom)
R. R. Thomson, Heriot-Watt Univ. (United Kingdom)
The Univ. of Edinburgh (United Kingdom)
M. G. Tanner, Heriot-Watt Univ. (United Kingdom)
The Univ. of Edinburgh (United Kingdom)


Published in SPIE Proceedings Vol. 10685:
Biophotonics: Photonic Solutions for Better Health Care VI
Jürgen Popp; Valery V. Tuchin; Francesco Saverio Pavone, Editor(s)

© SPIE. Terms of Use
Back to Top