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Proceedings Paper

Space-dependent temperature increase in human skin subsurface chromophores immediately following pulsed laser exposure
Author(s): J. Stuart Nelson; Thomas E. Milner; B. Samuel Tanenbaum; Dennis M. Goodman
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Paper Abstract

Specifying the distribution of laser energy within a tissue is the first step toward understanding and capitalizing on a variety of laser-tissue interactions. Whether photothermal, photochemical, or photomechanical in nature, laser-tissue interactions begin with the absorption of photon energy. The spatial distribution of photon absorption specifies the required laser exposure to be delivered and the extent of subsequent therapeutic action. Using infrared tomography (IRT), the broad, long term objective of this research is the development of a three-dimensional tomographic reconstruction algorithm (TRA) as a means to determine the: (1) initial space-dependent temperature increase in subsurface chromophores [(Delta) TCHR((xi) ,(eta) ,(zetz) ,t equals 0)] immediately following pulsed laser exposure; and (2) depths and physical dimensions of discrete subsurface chromophores. Analysis of the recorded time sequence of infrared emission images [(Delta) MCHR(x,y,t)] by longitudinal inversion and lateral deconvolution algorithms provides a direct means to determine the depths and physical dimensions of subsurface chromophores. Although our research is being shared with workers in a variety of disciplines, and pertinent to many clinical applications involving laser-induced photothermal mechanisms, we are particularly interested in addressing the problems associated with determination of the initial space-dependent temperature increase in subsurface chromophores in human skin in general, and port wine stain (PWS) blood vessels in particular.

Paper Details

Date Published: 19 January 1996
PDF: 12 pages
Proc. SPIE 2623, Medical Applications of Lasers III, (19 January 1996); doi: 10.1117/12.230352
Show Author Affiliations
J. Stuart Nelson, Univ. of California/Irvine (United States)
Thomas E. Milner, Beckman Laser Institute and Medical Clinic (United States)
B. Samuel Tanenbaum, Harvey Mudd College (United States)
Dennis M. Goodman, Lawrence Livermore National Lab. (United States)


Published in SPIE Proceedings Vol. 2623:
Medical Applications of Lasers III
Stephen G. Bown; Herbert J. Geschwind; Raimund Hibst; Frederic Laffitte; Giulio Maira; Roberto Pini; Hans-Dieter Reidenbach; Hans H. Scherer; Pasquale Spinelli, Editor(s)

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