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Proceedings Paper

Photoacoustic imaging to probe tumour oxygenation and oxidative stress dynamics (Conference Presentation)
Author(s): Sarah E. Bohndiek
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Paper Abstract

Hypoxia, or low oxygen partial pressure, is a common feature of many solid tumours, associated with therapy resistance and poor prognosis for cancer patients. This chemical feature of the tumour microenvironment represents an imbalance of blood oxygen supply and tissue oxygen demand. Given the prognostic significance of hypoxia, there is a clinical unmet need to provide validated, non-invasive, imaging biomarkers that can be used to detect and monitor the spatiotemporal distribution of hypoxia at the point of cancer diagnosis and during treatment. In this talk, I will give an overview of how photoacoustic imaging can address this unmet need, providing examples from both preclinical studies in mouse models of cancer and clinical studies in human patients.

Paper Details

Date Published: 15 March 2018
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Proc. SPIE 10493, Dynamics and Fluctuations in Biomedical Photonics XV, 104930N (15 March 2018); doi: 10.1117/12.2300504
Show Author Affiliations
Sarah E. Bohndiek, Univ. of Cambridge (United Kingdom)


Published in SPIE Proceedings Vol. 10493:
Dynamics and Fluctuations in Biomedical Photonics XV
Valery V. Tuchin; Kirill V. Larin; Martin J. Leahy; Ruikang K. Wang, Editor(s)

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