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Proceedings Paper

Treatment of relapse in herpes simplex on labial and facial areas and of primary herpes simplex on genital areas and "area pudenda" with low-power He-Ne laser or Acyclovir administered orally
Author(s): Mariano Velez-Gonzalez; Alejandro Urrea-Arbelaez; M. Nicolas; E. Serra-Baldrich; J. L. Perez; M. Pavesi; J. M.G. Camarasa; Mario A. Trelles
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Paper Abstract

Sixty patients (greater than 16 yrs old) suffering primary or relapse genital herpes simplex viruses (HSV) and relapse labial HSV were appointed for this study. Three or more relapses were experienced per year. Patients (under treatment) were divided into two groups (distribution areas), corresponding to either labial herpes or genital herpes. These groups were sub-divided into 3 groups. The total number of labial or facial HSV patients was 36 (10 in group 1, 12 in group 2, 14 in group 3) and 24 for genital, buttocks, or 'area pudenda' HSV patients (6 in group 1, 8 in group 2, 10 in group 3). The design was a randomized, double- blind study. The setting was hospital and outpatient. The patients diagnosed as having the HVS disease were sent to the dermatology department and were assigned to a group at random. Treatment was begun as follows: During the treatment signs and symptoms were assessed and after the treatment, the relapses were also assessed (biochemical and hematological tests before and after the treatment) and the diagnosis of the HSV type I and II. The statistical evaluation of the results was performed and carried out with the SPSS and BMDP program. The relapses of the herpes infection in the lips and the face were significantly reduced (p less than 0.026) in patients treated with laser He-Ne and laser He-Ne plus Acyclovir. The interim between the relapses also increased significantly (p less than 0.005) in relation with the group treated with Acyclovir. The duration of the herpetic eruptions was clearly reduced in all locations in patients treated with laser He-Ne plus Acyclovir. No differences were noted between patients treated with laser He-Ne only or Acyclovir only. Therefore it is probable that therapeutic synergism took place. In relation with this, laser He-Ne shows the same therapeutic efficacy as Acyclovir taken orally. The association of Acyclovir and laser Ne-Ne could be an alternative method for the treatment of HSV in the face. The number of relapses of the herpes infection in the genital, buttocks or 'area pudenda' and the interim between the relapses were not substantially modified with the treatment of laser He-Ne or laser Ne-Ne plus Acyclovir. Although a little difference exists in comparison with the patients treated with Acyclovir alone, a survey or an increased number of patients should be necessary.

Paper Details

Date Published: 15 January 1996
PDF: 8 pages
Proc. SPIE 2630, Effects of Low-Power Light on Biological Systems, (15 January 1996); doi: 10.1117/12.230040
Show Author Affiliations
Mariano Velez-Gonzalez, Hospital del Mar (Spain)
Alejandro Urrea-Arbelaez, Hospital del Mar (Spain)
M. Nicolas, Hospital del Mar (Spain)
E. Serra-Baldrich, Hospital del Mar (Spain)
J. L. Perez, Principes de Espana Hospital (Spain)
M. Pavesi, IMIM-Hospital del Mar (Spain)
J. M.G. Camarasa, Hospital del Mar (Spain)
Mario A. Trelles, Instituto Medico Vilafortuny (Spain)


Published in SPIE Proceedings Vol. 2630:
Effects of Low-Power Light on Biological Systems
Tiina I. Karu; Anthony R. Young, Editor(s)

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