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Proceedings Paper

Erlanger Microlightguidephotometer: a new way of monitoring local oxygen supply of tissue
Author(s): Jens Adler; Stefan Kuchenruether; W. Doblanzki; M. Georgieff
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Paper Abstract

Up to now objective criteria for the oxygen supply of tissue only arose from global parameters, for example heart-rate, blood-pressure, blood gases. A judgement of the local oxygen supply -- as an early indicator of organ dysfunction -- is almost impossible. The development of the Erlanger microlightguide photometer (EMPHO) for the first time allows the registration of local parameters as intracapillary hemoglobinoxigenation (HbO2). The instrument enables the measurement of hemoglobin spectra in tissue micro volumes and thus resolves the spatial heterogeneity of HbO2. Measurements were performed in healthy human volunteers. HbO2 was monitored at six points in the skin of the back of the hand. At each measuring site 2000 spectra were recorded. The measurements were performed during normoxia as well as during a period of hypoxia (FiO2 equals 0.1). It could be shown that changes in the distribution of HbO2 occur as an indicator of activated local regulatory mechanisms. This opens up the possibility of using the EMPHO for other organs, in order to investigate the relevance of these regulatory mechanisms under physiological and pathophysiological conditions.

Paper Details

Date Published: 15 January 1996
PDF: 12 pages
Proc. SPIE 2628, Optical and Imaging Techniques for Biomonitoring, (15 January 1996); doi: 10.1117/12.230003
Show Author Affiliations
Jens Adler, Univ. Hospital Ulm (Germany)
Stefan Kuchenruether, Univ. Hospital Ulm (Germany)
W. Doblanzki, Univ. Hospital Ulm (Germany)
M. Georgieff, Univ. Hospital Ulm (Germany)


Published in SPIE Proceedings Vol. 2628:
Optical and Imaging Techniques for Biomonitoring
Hans-Jochen Foth; Renato Marchesini; Halina Podbielska M.D.; Michel Robert-Nicoud; Herbert Schneckenburger, Editor(s)

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