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Proceedings Paper

Silicon microneedle array for minimally invasive human health monitoring
Author(s): Rosemary L. Smith; Scott D. Collins; Janice Duy; Timothy D. Minogue
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Paper Abstract

A silicon microneedle array with integrated microfluidic channels is presented, which is designed to extract dermal interstitial fluid (ISF) for biochemical analysis. ISF is a cell-free biofluid that is known to contain many of the same constituents as blood plasma, but the scope and dynamics of biomarker similarities are known for only a few components, most notably glucose. Dermal ISF is accessible just below the outer skin layer (epidermis), which can be reached and extracted with minimal sensation and tissue trauma by using a microneedle array. The microneedle arrays presented here are being developed to extract dermal ISF for off-chip profiling of nucleic acid constituents in order to identify potential biomarkers of disease. In order to assess sample volume requirements, preliminary RNA profiling was performed with suction blister ISF. The microneedles are batch fabricated using established silicon technology (low cost), are small in size, and can be integrated with sensors for on-chip analysis. This approach portends a more rapid, less expensive, self-administered assessment of human health than is currently achievable with blood sampling, especially in non-clinical and austere settings. Ultimately, a wearable device for monitoring a person’s health in any setting is envisioned.

Paper Details

Date Published: 19 February 2018
PDF: 7 pages
Proc. SPIE 10491, Microfluidics, BioMEMS, and Medical Microsystems XVI, 1049102 (19 February 2018); doi: 10.1117/12.2299264
Show Author Affiliations
Rosemary L. Smith, The Univ. of Maine (United States)
Scott D. Collins, The Univ. of Maine (United States)
Janice Duy, U.S. Army Medical Research Institute of Infectious Diseases (United States)
Timothy D. Minogue, U.S. Army Medical Research Institute of Infectious Diseases (United States)

Published in SPIE Proceedings Vol. 10491:
Microfluidics, BioMEMS, and Medical Microsystems XVI
Bonnie L. Gray; Holger Becker, Editor(s)

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