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Fluorescence endoscopy using fiber speckle illumination
Author(s): Shuhei Nakano; Takashi Katagiri; Yuji Matsuura
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Paper Abstract

An endoscopic fluorescence imaging system based on fiber speckle illumination is proposed. In this system, a multimode fiber for transmission of excitation laser light and collection of fluorescence is inserted into a conventional flexible endoscope. Since the excitation laser light has random speckle structure, one can detect fluorescence signal corresponding to the irradiation pattern if the sample contains fluorophores. The irradiation pattern can be captured by the endoscope camera when the excitation wavelength is within the sensitivity range of the camera. By performing multiple measurements while changing the irradiation pattern, a fluorescence image is reconstructed by solving a norm minimization problem. The principle of our method was experimentally demonstrated. A 2048 pixels image of quantum dots coated on a frosted glass was successfully reconstructed by 32 measurements. We also confirmed that our method can be applied on biological tissues.

Paper Details

Date Published: 13 February 2018
PDF: 7 pages
Proc. SPIE 10488, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVIII, 104880R (13 February 2018); doi: 10.1117/12.2296330
Show Author Affiliations
Shuhei Nakano, Tohoku Univ. (Japan)
Takashi Katagiri, Tohoku Univ. (Japan)
Yuji Matsuura, Tohoku Univ. (Japan)

Published in SPIE Proceedings Vol. 10488:
Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVIII
Israel Gannot, Editor(s)

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