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Plasmon-enhanced Raman detection of body-fluid components
Author(s): Paolo Matteini; Martina Banchelli; Marella De Angelis; Cristiano D'Andrea; Roberto Pini
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Paper Abstract

Plasmon-enhanced spectroscopies such as surface-enhanced Raman spectroscopy (SERS) concern the detection of enhanced optical responses of molecules in close proximity to plasmonic structures, which results in a strong increase in sensitivity. Recent advancements in nanofabrication methods have paved the way for a controlled design of tailor-made nanostructures with fine-tuning of their optical and surface properties. Among these, silver nanocubes (AgNCs) represent a convenient choice in SERS owing to intense electromagnetic fields localized at their extremities, which are further intensified in the gap regions between closely spaced nanoparticles. The integration of AgNCs assemblies within an optofluidic platform may confer potential for superior optical investigation due to a molecular enrichment on the plasmonic structures to collect an enhanced photonic response. We developed a novel sensing platform based on an optofluidic system involving assembled silver nanocubes of 50 nm in size for ultrasensitive SERS detection of biomolecules in wet conditions. The proposed system offers the perspective of advanced biochemical and biological characterizations of molecules as well as of effective detection of body fluid components and other molecules of biomedical interest in their own environment.

Paper Details

Date Published: 13 February 2018
PDF: 4 pages
Proc. SPIE 10488, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVIII, 104880W (13 February 2018); doi: 10.1117/12.2295086
Show Author Affiliations
Paolo Matteini, Istituto di Fisica Applicata "Nello Carrara" (Italy)
Martina Banchelli, Istituto di Fisica Applicata "Nello Carrara" (Italy)
Marella De Angelis, Istituto di Fisica Applicata "Nello Carrara" (Italy)
Cristiano D'Andrea, Istituto di Fisica Applicata "Nello Carrara" (Italy)
Roberto Pini, Istituto di Fisica Applicata "Nello Carrara" (Italy)


Published in SPIE Proceedings Vol. 10488:
Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVIII
Israel Gannot, Editor(s)

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