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Objective dynamic changes in lens curvature during accommodation using optical coherence tomography images (Conference Presentation)
Author(s): Siobhan Williams; Giovanni Gregori; Marco Ruggeri; Yu-Cherng Chang; Florence Cabot; Arthur Ho; Sonia Yoo; Jean-Marie Parel; Fabrice Manns

Paper Abstract

Purpose: To objectively quantify dynamic changes in lens shape during accommodation using two-dimensional OCT images Methods: In-vivo responses to an accommodative step stimulus of three subjects (aged 22, 39, and 45) were captured using a custom-made extended-depth SD-OCT system operating at 840 nm following an IRB-approved protocol (Ruggeri et al. 2012). Subjects focused on a visual accommodation target designed to produce an adjustable step stimulus of accommodation. Accommodative responses to 2-D and 4-D stimuli were captured ~1.5s before and ~4.5s after stimulation. Lens thickness, anterior curvature, and posterior curvature were measured using a newly-developed algorithm (validated using a calibration sphere). Dynamic changes in lens thickness and curvature were then fitted with an exponential model to produce time dependent constants. Results: All calibration OCT images were automatically analyzed in under 2 seconds. A radius of 7.793mm ± 0.051mm was calculated resulting in a difference of 2.4μm from the reported nominal value of the calibration sphere. Anterior lens radius decreased over time in all subjects. Radius of the posterior lens experienced a slight increase for all subjects. Conclusion: This study demonstrates the feasibility of quantifying the dynamic changes in lens curvature and thickness during accommodation using extended-depth OCT combined with a step accommodation stimulus and an automated segmentation algorithm.

Paper Details

Date Published: 14 March 2018
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Proc. SPIE 10474, Ophthalmic Technologies XXVIII, 1047419 (14 March 2018); doi: 10.1117/12.2295005
Show Author Affiliations
Siobhan Williams, Univ. of Miami (United States)
Bascom Palmer Eye Institute (United States)
Giovanni Gregori, Bascom Palmer Eye Institute (United States)
Marco Ruggeri, Bascom Palmer Eye Institute (United States)
Univ. of Miami (United States)
Yu-Cherng Chang, Univ. of Miami Miller School of Medicine (United States)
Univ. of Miami (United States)
Bascom Palmer Eye Institute (United States)
Florence Cabot, Bascom Palmer Eye Institute (United States)
Arthur Ho, Brien Holden Vision Institute (Australia)
The Univ. of New South Wales (Australia)
Univ. of Miami Miller School of Medicine (United States)
Sonia Yoo, Bascom Palmer Eye Institute (United States)
Jean-Marie Parel, Bascom Palmer Eye Institute (United States)
Univ. of Miami (United States)
Brien Holden Vision Institute (Australia)
Fabrice Manns, Univ. of Miami (United States)
Bascom Palmer Eye Institute (United States)


Published in SPIE Proceedings Vol. 10474:
Ophthalmic Technologies XXVIII
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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