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Proceedings Paper

Primary stage of photodestruction of malignant cells under photodynamic therapy of tumors
Author(s): Vasili A. Mostovnikov; Galina R. Mostovnikova; Vitali Yu Plavski; Antonina I. Tretjakova
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Paper Abstract

In this work we present the experimental results indicating that under photodynamic therapy the primary stage of the photodestruction of malignant cells is based on the irreversible photodestruction of glycolysis enzymes located, first of all, in mitochondria playing a key role in the energy supply for the tumor cells. It was shown that the formation of complexes between glycolysis enzymes and a sensitizer promotes an effective destruction of the formers. The formation of strong complexes was demonstrated for a number of glycolysis enzymes (glyceraldehyde-2-phosphate dehydrogenase, pyruvate kinase, lactate dehydrogenase) with the use of water-soluble pigments chlorin e6 and tetra(carboxyphenyl)porphyrin (T(CP)P) as sensitizers. The direct correlation was shown between the effectiveness of the photodestruction of enzyme molecules and the enzyme-sensitizer binding constant.

Paper Details

Date Published: 8 January 1996
PDF: 10 pages
Proc. SPIE 2728, CIS Selected Papers: Laser Use in Oncology, (8 January 1996); doi: 10.1117/12.229492
Show Author Affiliations
Vasili A. Mostovnikov, B.I. Stepanov Institute of Physics (Belarus)
Galina R. Mostovnikova, B.I. Stepanov Institute of Physics (Belarus)
Vitali Yu Plavski, B.I. Stepanov Institute of Physics (Belarus)
Antonina I. Tretjakova, B.I. Stepanov Institute of Physics (Belarus)

Published in SPIE Proceedings Vol. 2728:
CIS Selected Papers: Laser Use in Oncology
Andrei V. Ivanov; Mishik A. Kazaryan, Editor(s)

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