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Proceedings Paper

Vascular effect of photodynamic therapy
Author(s): Svyatoslav N. Fyodorov; V. G. Kopayeva; J. B. Andreev; Gelii V. Ponomarev; Eugeny Ph. Stranadko; H. M. Suchin
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Paper Abstract

Vascular effect of PDT has been studied in patients with corneal vascularized leucomas (10 patients) and in patients with corneal neovascularized transplant (3 patients). For vascularized leucomas the method of photodynamic therapy consisted of the local injection of dimegin (deiteroporphyrin derivative) into the space of the newly-formed vessels under operating microscope (opton) with the microneedle (diameter 200 microns) and corneal irradiation by the operating microscope light. For corneal neovascularized transplant the injection of photogem (hematoporphyrin derivative) intravenously were made with subsequent irradiation by light of dye laser (5 hours after the injection) with light density of 150 mW/cm2 for 15 minutes. In all the cases at the time of irradiation the aggregated blood flow was appeared, followed by blood flow stasis. In postoperative period the vessels disintegrated into separate fragments which disappeared completely after 10 - 15 days. Taking into account the data of light microscopy, the disappearance of the vessels took place as a result of the vascular endothelium lisis along the vascular walls. Neovascularized cornea and newly-formed vessels in tumor stroms have much in common. The vessel alterations study presented in this paper, may serve to specify the mechanism of photodynamic destruction of neovascularized stroma of tumor.

Paper Details

Date Published: 8 January 1996
PDF: 9 pages
Proc. SPIE 2728, CIS Selected Papers: Laser Use in Oncology, (8 January 1996); doi: 10.1117/12.229490
Show Author Affiliations
Svyatoslav N. Fyodorov, Intersectoral Research and Technology Complex Eye Microsurgery (Russia)
V. G. Kopayeva, Intersectoral Research and Technology Complex Eye Microsurgery (Russia)
J. B. Andreev, Intersectoral Research and Technology Complex Eye Microsurgery (Russia)
Gelii V. Ponomarev, Intersectoral Research and Technology Complex Eye Microsurgery (Russia)
Eugeny Ph. Stranadko, Intersectoral Research and Technology Complex Eye Microsurgery (Russia)
H. M. Suchin, Intersectoral Research and Technology Complex Eye Microsurgery (Russia)


Published in SPIE Proceedings Vol. 2728:
CIS Selected Papers: Laser Use in Oncology
Andrei V. Ivanov; Mishik A. Kazaryan, Editor(s)

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