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Proceedings Paper

Second-generation photosensitizers based on natural chlorines and bacteriochlorines
Author(s): Andrei F. Mironov
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Paper Abstract

New sensitizers for photodynamic therapy were synthesized on the base of biologically generated chlorins and bacteriochlorins. Derivatives of chlorophyll a and bacteriochlorophyll were prepared from the biomass of blue-green algae Spirulina Platensis and purple bacteria Rhodobacter Capsulatus, generated using specially designed photobioreactor. The strategy for chemical transformation of natural chlorophylls and bacteriochlorophyll has been discussed. Purpurin 18 and its dihydroanalogue bacteriopurpurin were chosen as the key intermediates. Modifications of peripheral substituents, such as introducing the new functional groups, hydrogenation of the B-pyrrolic ring, and insertion of amino acid residues gave the series of novel sensitizers, including water soluble chlorin p6 analogues, and derivatives with graded amphiphility for the studies of tumor accumulation in the malignant tissues.

Paper Details

Date Published: 8 January 1996
PDF: 15 pages
Proc. SPIE 2728, CIS Selected Papers: Laser Use in Oncology, (8 January 1996); doi: 10.1117/12.229483
Show Author Affiliations
Andrei F. Mironov, Lomonosov State Academy of Fine Chemical Technology (Russia)


Published in SPIE Proceedings Vol. 2728:
CIS Selected Papers: Laser Use in Oncology

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