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Proceedings Paper

Surface enhanced Raman spectroscopy for malaria diagnosis and intradermal measurements
Author(s): Quan Liu; Clement Yuen; Keren Chen; Jian Ju; Aoli Xiong; Peter Preiser
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Paper Abstract

The biomarkers of many diseases such as malaria can be found in intradermal measurements. We will present two surface enhanced Raman spectroscopy (SERS) based methods for the detection of malaria biomarkers in blood, which are comparable to or outperform the standard clinical method. To eliminate the need of drawing blood, we will also report a stainless-steel microneedle based probe for direct intradermal SERS measurements. Moreover, we developed a deformable agarose needle to reduce the risk of sharp injury and cross contamination due to needle reuse. Tests in skin phantoms for glucose measurements demonstrated accuracy comparable to those traditional methods requiring blood drawing.

Paper Details

Date Published: 23 February 2018
PDF: 14 pages
Proc. SPIE 10509, Plasmonics in Biology and Medicine XV, 1050902 (23 February 2018); doi: 10.1117/12.2294539
Show Author Affiliations
Quan Liu, Nanyang Technological Univ. (Singapore)
Clement Yuen, Nanyang Technological Univ. (Singapore)
Keren Chen, Nanyang Technological Univ. (Singapore)
Jian Ju, Nanyang Technological Univ. (Singapore)
Aoli Xiong, Nanyang Technological Univ. (Singapore)
Peter Preiser, Nanyang Technological Univ. (Singapore)


Published in SPIE Proceedings Vol. 10509:
Plasmonics in Biology and Medicine XV
Tuan Vo-Dinh; Joseph R. Lakowicz, Editor(s)

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