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Proceedings Paper

Quantitative dynamic MRI (QdMRI) volumetric analysis of pediatric patients with thoracic insufficiency syndrome
Author(s): Yubing Tong; Jayaram K. Udupa; E. Paul Wileyto; Caiyun Wu; Joseph M. McDonough; Anthony Capraro; Oscar H. Mayer; Drew A. Torigian; Robert M. Campbell
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Paper Abstract

The lack of standardizable objective diagnostic measurement techniques is a major hurdle in the assessment and treatment of pediatric patients with thoracic insufficiency syndrome (TIS). The aim of this paper is to explore quantitative dynamic MRI (QdMRI) volumetric parameters derived from thoracic dMRI in pediatric patients with TIS and the relationships between dMRI parameters and clinical measurements. 25 TIS patients treated with vertical expandable prosthetic titanium rib (VEPTR) surgery are included in this retrospective study. Left and right lungs at endinspiration and end-expiration are segmented from constructed 4D dMRI images. Lung volumes and excursion (or tidal) volumes of the left/right chest wall and hemi-diaphragms are computed. Commonly used clinical parameters include thoracic and lumbar Cobb angles and respiratory measurements from pulmonary function testing (PFT). 200 3D lungs in total (left & right, pre-operative & post-operative, end-inspiration & end-expiration) are segmented for analysis. Our analysis indicates that change of resting breathing rate (RR) following surgery is negatively correlated with that of QdMRI parameters. Chest wall tidal volumes and hemi-diaphragm tidal volumes increase significantly following surgery. Clinical parameter RR reduced after surgical treatment with P values around 0.06 but no significant differences were found on other clinical parameters. The significant increase in post-operative tidal volumes suggests a treatment-related improvement in lung capacity. The reduction of RR following surgery shows that breathing function is improved. The QdMRI parameters may offer an objective marker set for studying TIS, which is currently lacking.

Paper Details

Date Published: 12 March 2018
PDF: 6 pages
Proc. SPIE 10578, Medical Imaging 2018: Biomedical Applications in Molecular, Structural, and Functional Imaging, 1057806 (12 March 2018); doi: 10.1117/12.2294048
Show Author Affiliations
Yubing Tong, Univ. of Pennsylvania (United States)
Jayaram K. Udupa, Univ. of Pennsylvania (United States)
E. Paul Wileyto, Univ. of Pennsylvania (United States)
Caiyun Wu, Univ. of Pennsylvania (United States)
Joseph M. McDonough, Children's Hospital of Philadelphia (United States)
Anthony Capraro, Children's Hospital of Philadelphia (United States)
Oscar H. Mayer, Children's Hospital of Philadelphia (United States)
Drew A. Torigian, Univ. of Pennsylvania (United States)
Robert M. Campbell, Children's Hospital of Philadelphia (United States)


Published in SPIE Proceedings Vol. 10578:
Medical Imaging 2018: Biomedical Applications in Molecular, Structural, and Functional Imaging
Barjor Gimi; Andrzej Krol, Editor(s)

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