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Proceedings Paper

Algorithm enabled TOF-PET imaging with reduced scan time
Author(s): Zheng Zhang; Sean Rose; Jinghan Ye; Amy E. Perkins; Buxin Chen; Emil Y. Sidky; Chien-Min Kao; Chi-Hua Tung; Xiaochuan Pan
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Paper Abstract

Time-of-flight (TOF) positron emission tomography (PET) has gained remarkable development recently due to the advances in scintillator, silicon photomultipliers (SiPM), and fast electronics. However, current clinical reconstruction algorithms in TOF-PET are still based on ordered-subset-expectation-maximization (OSEM) and its variants, which may face challenges in non-conventional imaging applications, such as fast imaging within short scan time. In this work, we propose an image-TV constrained optimization problem, and tailor a primal- dual algorithm for solving the problem and reconstructing images. We collect list-mode data of a Jaszczak phantom with a prototype digital TOF-PET scanner. We focus on investigating image reconstruction from data collected within reduced scan time, and thus of lower count levels. Results of the study indicate that our proposed algorithm can 1) yield image reconstruction with suppressed noise, extended axial volume coverage, and improved spatial resolution over that obtained in conventional reconstructions, and 2) yield reconstructions with potential clinical utility from data collected within shorter scan time.

Paper Details

Date Published: 9 March 2018
PDF: 5 pages
Proc. SPIE 10573, Medical Imaging 2018: Physics of Medical Imaging, 105733T (9 March 2018); doi: 10.1117/12.2294045
Show Author Affiliations
Zheng Zhang, The Univ. of Chicago (United States)
Sean Rose, The Univ. of Chicago (United States)
Jinghan Ye, Philips Healthcare (United States)
Amy E. Perkins, Philips Healthcare (United States)
Buxin Chen, The Univ. of Chicago (United States)
Emil Y. Sidky, The Univ. of Chicago (United States)
Chien-Min Kao, The Univ. of Chicago (United States)
Chi-Hua Tung, Philips Healthcare (United States)
Xiaochuan Pan, The Univ. of Chicago (United States)


Published in SPIE Proceedings Vol. 10573:
Medical Imaging 2018: Physics of Medical Imaging
Joseph Y. Lo; Taly Gilat Schmidt; Guang-Hong Chen, Editor(s)

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