Share Email Print
cover

Proceedings Paper • new

An investigation into how the radiotherapy dose response of normal appearing brain tissue in glioma patients influences ADC measurements
Author(s): Haris Shuaib; Lucy Brazil; Thomas C. Booth
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

Functional diffusion map (fDM) analysis has been shown to be potentially useful in categorizing treatment response in glioma patients.1, 2 Such fDMs are created using subtracted longitudinal ADC images, which are segmented to quantify regions of significant increases and decreases in ADC values. Thresholds demarcating significant change have been defined in the literature by sampling longitudinal changes in contralateral normal appearing brain tissue (NABT) in the patient population that was being studied1, 2 . A recent publication has shown that the use of contralateral NABT to aid absolute quantification of CBV and CBF values due to radiation induced changes to dynamic susceptibility contrast MRI (DSC) parameters is inappropriate.3 We have investigated how the radiotherapy (RT) dose response of contralateral NABT influences ADC measurements.

Paper Details

Date Published: 9 March 2018
PDF: 6 pages
Proc. SPIE 10573, Medical Imaging 2018: Physics of Medical Imaging, 105732R (9 March 2018); doi: 10.1117/12.2293797
Show Author Affiliations
Haris Shuaib, Guy's and St Thomas' NHS Foundation Trust (United Kingdom)
Lucy Brazil, Guy's and St Thomas' NHS Foundation Trust (United Kingdom)
Thomas C. Booth, King's College Hospital NHS Foundation Trust (United Kingdom)


Published in SPIE Proceedings Vol. 10573:
Medical Imaging 2018: Physics of Medical Imaging
Joseph Y. Lo; Taly Gilat Schmidt; Guang-Hong Chen, Editor(s)

© SPIE. Terms of Use
Back to Top