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Proceedings Paper

Classifying Alzheimer's disease using probability distribution distance of fractional anisotropy and trace from diffusion tensor imaging in combination with whole-brain segmentations
Author(s): Yuanyuan Wei; Zhibin Chen; Xiaoying Tang
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Paper Abstract

Using diffusion tensor imaging (DTI), we developed and validated an automated classification procedure for Alzheimer’s disease (AD); specifically, DTI-derived fractional anisotropy (FA) and trace images from 22 AD subjects and 15 healthy control (HC) subjects were used. A total of four types of region of interest (ROI)-based features were tested, including the probability distribution distances of FA and trace images, within each of 162 whole-brain segmented ROIs, under both discrete and continuous intensity distribution modeling. The continuous modeling was conducted through a mixture of Gaussians, the parameters of which were estimated using maximum likelihood estimation via the expectation-maximization algorithm. We used principal component analysis (PCA) to reduce the dimension of the feature space and then linear discriminant analysis and support vector machine (SVM) for automated classification. According to our 10-times 10-fold cross-validation experiments, using the combination of PCA and linear SVM, the continuous distance of the trace image yielded the best classification performance with the accuracy being 87.84%±3.43% and the area under the receiver operating characteristic curve being 0.9121±0.0176, indicating its great potential as an effective AD biomarker.

Paper Details

Date Published: 12 March 2018
PDF: 9 pages
Proc. SPIE 10578, Medical Imaging 2018: Biomedical Applications in Molecular, Structural, and Functional Imaging, 1057802 (12 March 2018); doi: 10.1117/12.2293449
Show Author Affiliations
Yuanyuan Wei, Sun Yat-Sen Univ. (China)
Carnegie Mellon Univ. (United States)
Zhibin Chen, Sun Yat-Sen Univ. (China)
Carnegie Mellon Univ. (United States)
Xiaoying Tang, Sun Yat-Sen Univ. (China)
Sun Yat-Sen Univ.-Carnegie Mellon Univ. Shunde International Joint Research Institute (China)

Published in SPIE Proceedings Vol. 10578:
Medical Imaging 2018: Biomedical Applications in Molecular, Structural, and Functional Imaging
Barjor Gimi; Andrzej Krol, Editor(s)

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