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Improving performance of breast cancer risk prediction using a new CAD-based region segmentation scheme
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Paper Abstract

Objective of this study is to develop and test a new computer-aided detection (CAD) scheme with improved region of interest (ROI) segmentation combined with an image feature extraction framework to improve performance in predicting short-term breast cancer risk. A dataset involving 570 sets of "prior" negative mammography screening cases was retrospectively assembled. In the next sequential "current" screening, 285 cases were positive and 285 cases remained negative. A CAD scheme was applied to all 570 "prior" negative images to stratify cases into the high and low risk case group of having cancer detected in the "current" screening. First, a new ROI segmentation algorithm was used to automatically remove useless area of mammograms. Second, from the matched bilateral craniocaudal view images, a set of 43 image features related to frequency characteristics of ROIs were initially computed from the discrete cosine transform and spatial domain of the images. Third, a support vector machine model based machine learning classifier was used to optimally classify the selected optimal image features to build a CAD-based risk prediction model. The classifier was trained using a leave-one-case-out based cross-validation method. Applying this improved CAD scheme to the testing dataset, an area under ROC curve, AUC = 0.70±0.04, which was significantly higher than using the extracting features directly from the dataset without the improved ROI segmentation step (AUC = 0.63±0.04). This study demonstrated that the proposed approach could improve accuracy on predicting short-term breast cancer risk, which may play an important role in helping eventually establish an optimal personalized breast cancer paradigm.

Paper Details

Date Published: 27 February 2018
PDF: 6 pages
Proc. SPIE 10575, Medical Imaging 2018: Computer-Aided Diagnosis, 105750P (27 February 2018); doi: 10.1117/12.2293361
Show Author Affiliations
Morteza Heidari, The Univ. of Oklahoma (United States)
Abolfazl Zargari Khuzani, The Univ. of Oklahoma (United States)
Gopichandh Danala, The Univ. of Oklahoma (United States)
Yuchen Qiu , The Univ. of Oklahoma (United States)
Bin Zheng, The Univ. of Oklahoma (United States)


Published in SPIE Proceedings Vol. 10575:
Medical Imaging 2018: Computer-Aided Diagnosis
Nicholas Petrick; Kensaku Mori, Editor(s)

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