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Proceedings Paper

Direct prior regularization from anatomical images for cone beam x-ray luminescence computed tomography reconstruction
Author(s): Peng Gao; Junyan Rong; Tianshuai Liu; Wenli Zhang; Huangsheng Pu; Zhengrong Liang; Hongbing Lu
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Paper Abstract

Cone beam X-ray luminescence computed tomography (CB-XLCT) has recently been proposed as a new imaging modality for biological imaging application. Compared with other XLCT systems such as pencil beam XLCT and narrow beam XLCT, CB-XLCT can achieve fast imaging, where the speed is essential to small animal in vivo imaging studies. However, due to the high degree of light scattering in biological tissues, the CB-XLCT reconstruction is an ill-posed problem, which can result in poor image quality such as low spatial resolution. As a hybrid CT/optical imaging technique, the image quality is conjected to be improved substantially with the structural guidance from the anatomical images of the CT component. For that purpose, in this paper, a direct prior regularization method is proposed by introducing anatomical information directly into the CB-XLCT reconstruction. The primary advantage of the proposed method is that it does not require segmentation of targets in the anatomical images. Phantom experiments with different edge-to-edge distance (EED) were performed to realize the proposed approach's feasibility. Phantom experiments results indicate that the proposed direct regularization method can separate two luminescent targets with an EED of 0 mm. Compared with no-prior reconstruction methods such as ART and adaptive Tikhonov methods, the proposed method can significantly improve the imaging resolution of CB-XLCT.

Paper Details

Date Published: 12 March 2018
PDF: 6 pages
Proc. SPIE 10578, Medical Imaging 2018: Biomedical Applications in Molecular, Structural, and Functional Imaging, 105781I (12 March 2018); doi: 10.1117/12.2293205
Show Author Affiliations
Peng Gao, Fourth Military Medical Univ. (China)
Junyan Rong, Fourth Military Medical Univ. (China)
Tianshuai Liu, Fourth Military Medical Univ. (China)
Wenli Zhang, Fourth Military Medical Univ. (China)
Huangsheng Pu, Fourth Military Medical Univ. (China)
Zhengrong Liang, Stony Brook Univ. (United States)
Hongbing Lu, Fourth Military Medical Univ. (China)

Published in SPIE Proceedings Vol. 10578:
Medical Imaging 2018: Biomedical Applications in Molecular, Structural, and Functional Imaging
Barjor Gimi; Andrzej Krol, Editor(s)

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