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Proceedings Paper

Novel fiber optic-based needle redox imager for cancer diagnosis
Author(s): Udayakumar Kanniyappan; He N. Xu; Qinggong Tang; Brandon Gaitan; Yi Liu; Lin Z. Li; Yu Chen
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Paper Abstract

Despite various technological advancements in cancer diagnosis, the mortality rates were not decreased significantly. We aim to develop a novel optical imaging tool to assist cancer diagnosis effectively. Fluorescence spectroscopy/imaging is a fast, rapid, and minimally invasive technique which has been successfully applied to diagnosing cancerous cells/tissues. Recently, the ratiometric imaging of intrinsic fluorescence of reduced nicotinamide adenine dinucleotide (NADH) and flavin adenine dinucleotide (FAD), as pioneered by Britton Chance and the co-workers in 1950-70’s, has gained much attention to quantify the physiological parameters of living cells/tissues. The redox ratio, i.e., FAD/(FAD+NADH) or FAD/NADH, has been shown to be sensitive to various metabolic changes in in vivo and in vitro cells/tissues. Optical redox imaging has also been investigated for providing potential imaging biomarkers for cancer transformation, aggressiveness, and treatment response. Towards this goal, we have designed and developed a novel fiberoptic-based needle redox imager (NRI) that can fit into an 11G clinical coaxial biopsy needle for real time imaging during clinical cancer surgery. In the present study, the device is calibrated with tissue mimicking phantoms of FAD and NADH along with various technical parameters such as sensitivity, dynamic range, linearity, and spatial resolution of the system. We also conducted preliminary imaging of tissues ex vivo for validation. We plan to test the NRI on clinical breast cancer patients. Once validated this device may provide an effective tool for clinical cancer diagnosis.

Paper Details

Date Published: 26 February 2018
PDF: 8 pages
Proc. SPIE 10489, Optical Biopsy XVI: Toward Real-Time Spectroscopic Imaging and Diagnosis, 104890J (26 February 2018); doi: 10.1117/12.2293133
Show Author Affiliations
Udayakumar Kanniyappan, Univ. of Maryland, College Park (United States)
He N. Xu, The Univ. of Pennsylvania (United States)
Qinggong Tang, Univ. of Maryland, College Park (United States)
Brandon Gaitan, Univ. of Maryland, College Park (United States)
Yi Liu, Univ. of Maryland, College Park (United States)
Lin Z. Li, The Univ. of Pennsylvania (United States)
Yu Chen, Univ. of Maryland, College Park (United States)

Published in SPIE Proceedings Vol. 10489:
Optical Biopsy XVI: Toward Real-Time Spectroscopic Imaging and Diagnosis
Robert R. Alfano; Stavros G. Demos, Editor(s)

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