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Proceedings Paper

Skull segmentation from MR scans using a higher-order shape model based on convolutional restricted Boltzmann machines
Author(s): Oula Puonti; Koen Van Leemput; Jesper D. Nielsen; Christian Bauer; Hartwig Roman Siebner; Kristoffer H. Madsen; Axel Thielscher
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Paper Abstract

Transcranial brain stimulation (TBS) techniques such as transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS) and others have seen a strong increase as tools in therapy and research within the last 20 years. In order to precisely target the stimulation, it is important to accurately model the individual head anatomy of a subject. Of particular importance is accurate reconstruction of the skull, as it has the strongest impact on the current pathways due to its low conductivity. Thus providing automated tools, which can reliably reconstruct the anatomy of the human head from magnetic resonance (MR) scans would be highly valuable for the application of transcranial stimulation methods. These head models can also be used to inform source localization methods such as EEG and MEG. Automated segmentation of the skull from MR images is, however, challenging as the skull emits very little signal in MR. In order to avoid topological defects, such as holes in the segmentations, a strong model of the skull shape is needed. In this paper we propose a new shape model for skull segmentation based on the so-called convolutional restricted Boltzmann machines (cRBMs). Compared to traditionally used lower-order shape models, such as pair-wise Markov random fields (MRFs), the cRBMs model local shapes in larger spatial neighborhoods while still allowing for efficient inference. We compare the skull segmentation accuracy of our approach to two previously published methods and show significant improvement.

Paper Details

Date Published: 2 March 2018
PDF: 9 pages
Proc. SPIE 10574, Medical Imaging 2018: Image Processing, 1057404 (2 March 2018); doi: 10.1117/12.2293073
Show Author Affiliations
Oula Puonti, Copenhagen Univ. Hospital Hvidovre (Denmark)
Technical Univ. of Denmark (Denmark)
Koen Van Leemput, Technical Univ. of Denmark (Denmark)
Massachusetts General Hospital, Harvard Medical School (United States)
Jesper D. Nielsen, Copenhagen Univ. Hospital Hvidovre (Denmark)
Technical Univ. of Denmark (Denmark)
Christian Bauer, Copenhagen Univ. Hospital Hvidovre (Denmark)
Hartwig Roman Siebner, Copenhagen Univ. Hospital Hvidovre (Denmark)
Copenhagen Univ. Hospital Bispebjerg (Denmark)
Kristoffer H. Madsen, Copenhagen Univ. Hospital Hvidovre (Denmark)
Technical Univ. of Denmark (Denmark)
Axel Thielscher, Copenhagen Univ. Hospital Hvidovre (Denmark)
Technical Univ. of Denmark (Denmark)


Published in SPIE Proceedings Vol. 10574:
Medical Imaging 2018: Image Processing
Elsa D. Angelini; Bennett A. Landman, Editor(s)

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