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A rapid, robust multi-echo phase unwrapping method for quantitative susceptibility mapping (QSM) using strategically acquired gradient echo (STAGE) data acquisition
Author(s): Yongsheng Chen; Saifeng Liu; Yan Kang; E. Mark Haacke
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Paper Abstract

Purpose: To unwrap multi-echo phase images for quantitative susceptibility mapping (QSM) in a rapid and robust manner without using complicated search algorithms. Background: Since QSM requires unaliased phase images as input, a reliable 3D phase unwrapping step is essential to reconstruct susceptibility maps. However, this is usually one of the most time-consuming steps in QSM, especially for multi-echo data acquisition. Methods: Strategically acquired gradient echo (STAGE) data are used to provide six flow compensated images with echo times of 2.5 ms, 7.5 ms, 8.75 ms, 12.5 ms, 17.5 ms and 18.75 ms. An unaliased phase image with an effective echo time of 1.25 ms can be created by a complex division between 7.5 ms and 8.75 ms. Using this short pseudo-echo data along with the acquired 2.5 ms data, all other echoes can be unwrapped using a bootstrapping approach. Results: The six echoes (384 × 288 × 64 × 6 voxels) acquired using STAGE data acquisition were unwrapped successfully. This resulted in reliable self-consistent QSM images in only 1 second compared to the quality guided 3DSRNCP algorithm, which took 137 seconds, and the Laplacian based algorithm, which took 23 seconds on the same computer. Conclusions: The proposed bootstrapping multi-echo unwrapping method provides a rapid, robust phase unwrapping method on a voxel-by-voxel basis for online QSM reconstruction.

Paper Details

Date Published: 9 March 2018
PDF: 8 pages
Proc. SPIE 10573, Medical Imaging 2018: Physics of Medical Imaging, 105732U (9 March 2018); doi: 10.1117/12.2292951
Show Author Affiliations
Yongsheng Chen, Northeastern Univ. (China)
MRI Institute for Biomedical Research (United States)
Wayne State Univ. (United States)
Saifeng Liu, MRI Institute for Biomedical Research (United States)
Yan Kang, Northeastern Univ. (China)
E. Mark Haacke, Northeastern Univ. (China)
MRI Institute for Biomedical Research (United States)
Wayne State Univ. (United States)

Published in SPIE Proceedings Vol. 10573:
Medical Imaging 2018: Physics of Medical Imaging
Joseph Y. Lo; Taly Gilat Schmidt; Guang-Hong Chen, Editor(s)

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