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Proceedings Paper

Diffusion tensor imaging of the spine in pediatric patients
Author(s): Bhavesh Ramkorun; Samantha By; Bryson Reynolds; Seth Smith; Patrick Couture; Aashim Bhatia
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Paper Abstract

Quantitative imaging of the human spinal cord may provide information for diagnosis and prognosis of multiple pathologies. Diffusion tensor imaging (DTI) of the spinal cord in pediatric populations may offer quantitative indices to assess pathologies such as Chiari I malformation, spinal dysraphic defects including myelomeningocele, and tethered cord. We obtained DTI of the spine in 19 pediatric patients at Vanderbilt Children’s Hospital. 14 patients were identified as normal, and 5 patients were diagnosed with neurological disorders localized to the spinal cord, including Chiari I, tethered cord, and an intra-spinal tumor. The ages ranged 1 to 16 years old (mean age: 7 years, SD: 4 years). Fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were calculated from DTI and spinal cord volumes of interest were assessed. Data from control patients were used to define the range of normal values, and patients with diagnosed disorders affecting the cord were compared against this normal range. DTI data showed significant differences (p<0.05) in FA, AD, and RD between the conus medularis and thoracolumbar cord. Patients with tethered cord demonstrated higher FA, MD, and AD in the conus, and higher AD in the in thoracolumbar cord. The Chiari I patient had higher MD and AD in cervical cord. Whereas, the spinal tumor patient demonstrated no significant trends in the cervical cord.

Paper Details

Date Published: 12 March 2018
PDF: 7 pages
Proc. SPIE 10578, Medical Imaging 2018: Biomedical Applications in Molecular, Structural, and Functional Imaging, 1057827 (12 March 2018); doi: 10.1117/12.2292832
Show Author Affiliations
Bhavesh Ramkorun, Berea College (United States)
Vanderbilt Univ. Institute of Imaging Science (United States)
Samantha By, Vanderbilt Univ. Institute of Imaging Science (United States)
Vanderbilt Univ. (United States)
Bryson Reynolds, Vanderbilt Univ. Institute of Imaging Science (United States)
Seth Smith, Vanderbilt Univ. Institute of Imaging Science (United States)
Vanderbilt Univ. (United States)
Vanderbilt Univ. Medical Ctr. (United States)
Patrick Couture, Vanderbilt Univ. Medical Ctr. (United States)
Aashim Bhatia, Vanderbilt Univ. Medical Ctr. (United States)


Published in SPIE Proceedings Vol. 10578:
Medical Imaging 2018: Biomedical Applications in Molecular, Structural, and Functional Imaging
Barjor Gimi; Andrzej Krol, Editor(s)

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