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Proceedings Paper

Mie scattering characterization by ultra-spectral illumination using micro-sized tunable liquid crystal optical filters (Conference Presentation)
Author(s): Fartash Vasefi; Russell Barbour; Caleb Stoltzfus; Zeb Barber; Daniel Farkas

Paper Abstract

We developed a confocal microscope and ultra-spectral light source containing Liquid Crystal Arrayed Microcavities (LCAM) as a new technology for controlled ultra-narrow optical filtering (FWHM ∼0.1 nm). LCAMs use picoliter volume Fabry–Perot-type optical cavities filled with liquid crystal for wavelength tuning. With sub-nanometer spectral resolution, we measured spectral resonance from scattering particles to validate the measurements with simulation results. We measured chicken liver and breast muscle, pig skin and muscle and compared with results from literature. The main application is the estimation of nuclear size in biological tissues for noninvasive assessment equivalent to histopathology.

Paper Details

Date Published: 11 June 2018
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Proc. SPIE 10497, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XVI, 104971D (11 June 2018); doi: 10.1117/12.2292620
Show Author Affiliations
Fartash Vasefi, Spectral Molecular Imaging, Inc. (United States)
Russell Barbour, Spectral Molecular Imaging, Inc. (United States)
Advanced Microcavity Sensors LLC (United States)
Caleb Stoltzfus, Montana State Univ. (United States)
Advanced Microcavity Sensors LLC (United States)
Zeb Barber, Montana State Univ. (United States)
Daniel Farkas, Spectral Molecular Imaging, Inc. (United States)
The Univ. of Southern California (United States)


Published in SPIE Proceedings Vol. 10497:
Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XVI
Daniel L. Farkas; Dan V. Nicolau; Robert C. Leif, Editor(s)

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