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Fluorescent humanized anti-CEA antibody specifically labels metastatic pancreatic cancer in a patient-derived orthotopic xenograft (PDOX) mouse model
Author(s): Thinzar M. Lwin; Kentaro Miyake; Takashi Murakami; Jonathan C. DeLong; Paul J. Yazaki; John E. Shivley; Bryan Clary; Robert M. Hoffman; Michael Bouvet
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Paper Abstract

Specific tumor targeting can result in selective labeling of cancer in vivo for surgical navigation. In the present study, we show that the use of an anti-CEA antibody conjugated to the near-infrared (NIR) fluorescent dye, IRDye800CW, can selectively target and label pancreatic cancer and its metastases in a clinically relevant patient derived xenograft mouse model.

Paper Details

Date Published: 1 March 2018
PDF: 10 pages
Proc. SPIE 10478, Molecular-Guided Surgery: Molecules, Devices, and Applications IV, 104780O (1 March 2018); doi: 10.1117/12.2292546
Show Author Affiliations
Thinzar M. Lwin, Univ. of California, San Diego (United States)
Kentaro Miyake, Univ. of California, San Diego (United States)
AntiCancer, Inc. (United States)
Yokohama City Univ. (Japan)
Takashi Murakami, Univ. of California, San Diego (United States)
AntiCancer, Inc. (United States)
Yokohama City Univ. (Japan)
Jonathan C. DeLong, Univ. of California, San Diego (United States)
Paul J. Yazaki, City of Hope National Medical Ctr. (United States)
John E. Shivley, City of Hope National Medical Ctr. (United States)
Bryan Clary, Univ. of California, San Diego (United States)
Robert M. Hoffman, Univ. of California, San Diego (United States)
AntiCancer, Inc. (United States)
Michael Bouvet, Univ. of California, San Diego (United States)
VA San Diego Healthcare System (United States)


Published in SPIE Proceedings Vol. 10478:
Molecular-Guided Surgery: Molecules, Devices, and Applications IV
Brian W. Pogue; Sylvain Gioux; Greg Biggs, Editor(s)

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