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Optimization of a multi-color adaptive optics scanning laser ophthalmoscope design with diffraction-limited illumination and collection for high-throughput imaging (Conference Presentation)
Author(s): Francesco LaRocca; Sanam Mozaffari; Volker Jaedicke; Austin Roorda
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Paper Abstract

Current-generation adaptive optics scanning laser ophthalmoscopes (AOSLO) are typically able to compensate for the optical aberrations of the human eye and achieve diffraction-limited illumination over a wide vergence range. However, to maximize the light collection efficiency of such a system, it is also necessary to have a collection path that is diffraction-limited for each imaging channel. Although it is trivial to achieve a high collection efficiency for a single channel AOSLO or a multi-channel AOSLO with minimal vergence differences between channels, for larger vergence differences, a careful consideration of the collection optics and their position and orientation within the collection path is needed. We present a methodology and system design for achieving diffraction-limited performance in both the illumination and collection paths of a multi-color AOSLO. The system consists of three imaging channels spanning different wavelength ranges (543 ± 11 nm, 680 ± 11 nm, and 840 ± 6 nm, respectively) and one near-infrared wavefront sensing channel (940 ± 5 nm). The maximum vergence difference between channels (measured at the exit pupil of the system) is ~1.2 diopters to compensate for the chromatic focal shift of the human eye. Preliminary imaging results from a healthy human adult volunteer demonstrate the system’s ability to resolve the foveal cone mosaic in all three imaging channels.

Paper Details

Date Published: 14 March 2018
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Proc. SPIE 10474, Ophthalmic Technologies XXVIII, 104740F (14 March 2018); doi: 10.1117/12.2292090
Show Author Affiliations
Francesco LaRocca, Univ. of California, Berkeley (United States)
Sanam Mozaffari, Univ. of California, Berkeley (United States)
Volker Jaedicke, Univ. of California, Berkeley (United States)
Austin Roorda, Univ. of California, Berkeley (United States)


Published in SPIE Proceedings Vol. 10474:
Ophthalmic Technologies XXVIII
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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