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Investigation in clinical potential of polarization sensitive optical coherence tomography in laryngeal tumor model study
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Paper Abstract

Polarization-sensitive optical coherence tomography (PS-OCT) is capable of measuring tissue birefringence. It has been widely applied to access the birefringence in tissues such as skin and cartilage. The vocal cord tissue consists of three anatomical layers from the surface to deep inside, the epithelium that contains almost no collagen, the lamina propria that is composed with abundant collagen, and the vocalis muscle layer. Due to the variation in the organization of collagen fibers, the different tissue layers show different tissue birefringence, which can be evaluated by PS-OCT phase retardation measurement. Furthermore, collagen fibers in healthy connective tissues are usually well organized, which provides relatively high birefringence. When the collagen organization is destroyed by diseases such as tumor, the birefringence of the tissue will decrease. In this study, a rabbit laryngeal tumor model with different stages of tumor progression is investigated ex-vivo by PS-OCT. The PS-OCT images show a gradual decrease in birefringence from normal tissue to severe tumor tissue. A phase retardation slope-based analysis is conducted to distinguish the epithelium, lamina propria, and muscle layers, respectively. The phase retardation slope quantifies the birefringence in different layers. The quantitative study provides a more detailed comparison among different stages of the rabbit laryngeal tumor model. The PS-OCT result is validated by the corresponding histology images of the same samples.

Paper Details

Date Published: 14 February 2018
PDF: 6 pages
Proc. SPIE 10483, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXII, 1048339 (14 February 2018); doi: 10.1117/12.2292021
Show Author Affiliations
Xin Zhou, The Univ. of British Columbia (Canada)
Chulho Oak, Kosin Univ. College of Medicine (Korea, Republic of)
Yeh-Chan Ahn, Pukyong National Univ. (Korea, Republic of)
Sung Won Kim, Kosin Univ. College of Medicine (Korea, Republic of)
Shuo Tang, The Univ. of British Columbia (Canada)


Published in SPIE Proceedings Vol. 10483:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXII
Joseph A. Izatt; James G. Fujimoto; Valery V. Tuchin, Editor(s)

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