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Proceedings Paper

Imaging and navigation of remote controlled nanostructured carriers for theranostics (Conference Presentation)
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Paper Abstract

The modern medicine requires the new type of drug delivery carriers that will combine functions of in vivo navigation and visualization ability to deploy drug in controllable manner, including external triggering. This combination can be realized by multifunctional carriers produced by layer-by-layer assembly method. The carrier biodistribution can be controlled by a chosen mode of in vivo administration. Realization for chemical targeted delivery based on surface modification are not working well in vivo due to the corona effect [Kreyling W. et al., Nature Nanotech., 2015, 619]. Thus, physical targeting of drug delivery is more promising approach. It can be realized by gradient of magnetic field [Voronin D. et al., ACS App. Mater. & Interfaces, 2017, 6885], optical tweezers [Stetciura I. et al., Analyst, 2015,4981]. It was demonstrated that the sensitivity of nanostructured carriers to external influences as laser irradiation, ultrasound treatment can be changed by variation of volume fraction and chemical composition of inorganic nanoparticles in the carrier shell [Korolovych V. et al., PCCP, 2016,2389]. Same approach is applied for nanostructured carriers (NCs) imaging by MRI [German S. et al., PCCP, 2016, 32238], OCT [Genina E. et al., Biomed.Opt.Express, 2016, 2082] and photoacoustic method [Yashchenok A. et al., J. Biophotonics, 2016, 792] using magnetite and gold nanoparticles as contrast agents, respectively. Obtained NCs can be used as drug delivery systems including drug depot, combined much functionalities as navigation and visualization, in vivo monitoring of biochemical process, remote activated release of bioactive substances.

Paper Details

Date Published: 14 March 2018
Proc. SPIE 10479, Light-Based Diagnosis and Treatment of Infectious Diseases, 104790F (14 March 2018); doi: 10.1117/12.2291963
Show Author Affiliations
Marina Novoselova, Saratov State Univ. (Russian Federation)
Sergey V. German, Saratov State Univ. (Russian Federation)
Ekaterina I. Galanzha, Univ. of Arkansas for Medical Sciences (United States)
Valery V. Tuchin, Saratov State Univ. (Russian Federation)
National Research Tomsk State Univ. (Russian Federation)
Precision Mechanics and Control Institute, Russian Academy of Sciences (Russian Federation)
Vladimir P. Zharov, Univ. of Arkansas for Medical Sciences (United States)
Dmitry Gorin, Saratov State Univ. (Russian Federation)
Skolkovo Institute of Science and Technology (Russian Federation)
Elina A. Genina, Saratov State Univ. (Russian Federation)
National Research Tomsk State Univ. (Russian Federation)

Published in SPIE Proceedings Vol. 10479:
Light-Based Diagnosis and Treatment of Infectious Diseases
Tianhong Dai, Editor(s)

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