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Proceedings Paper

Light distributors for photodynamic therapy
Author(s): Hubert van den Bergh; Jerome C. Mizeret; Jean-Francois Theumann; Alain Woodtli; Roland Bays; D. Robert; P. Thielen; J. M. Philippoz; Daniel Braichotte; Martin Forrer; Jean-Francois Savary; Philippe Monnier; Georges A. Wagnieres
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Paper Abstract

A brief overview is given of light distributors developed by our group in Lausanne for photodynamic therapy (PDT) of cancer. We focus on fiberoptic devices which have to a large extent been tested over the years in the clinic for PDT of the upper aerodigestive tract, the tracheobronchial tree, the esophagus, the uterus, and the skin. Both surface and interstitial light distributors are discussed. Several different physical principles for obtaining the desired light intensity distribution in tissue are demonstrated, including the use of specially shaped reflecting surfaces, light scattering and refraction by particles, the use of flexible highly reflecting balloons, controlled fiber core surface roughening, and microlenses. PDT can be improved using 'intelligent' light distributors, which permit the measurement of the light intensity reflected from the irradiated surface, as well as the dye fluorescence signals. Both are measured in situ and in real time during the treatment. The use of such devices, which can measure photobleaching kinetics, and enable one to adjust the light dose to the observed dye fluorescence signals, thus giving better PDT control, is discussed.

Paper Details

Date Published: 3 January 1995
PDF: 26 pages
Proc. SPIE 2631, Medical and Fiber Optic Sensors and Delivery Systems, (3 January 1995); doi: 10.1117/12.229182
Show Author Affiliations
Hubert van den Bergh, Swiss Federal Institute of Technology (Switzerland)
Jerome C. Mizeret, Swiss Federal Institute of Technology (Switzerland)
Jean-Francois Theumann, Swiss Federal Institute of Technology (Switzerland)
Alain Woodtli, Swiss Federal Institute of Technology (Switzerland)
Roland Bays, Swiss Federal Institute of Technology (Switzerland)
D. Robert, Swiss Federal Institute of Technology (Switzerland)
P. Thielen, Swiss Federal Institute of Technology (Switzerland)
J. M. Philippoz, Swiss Federal Institute of Technology (Switzerland)
Daniel Braichotte, Swiss Federal Institute of Technology (Switzerland)
Martin Forrer, Swiss Federal Institute of Technology (Switzerland)
Jean-Francois Savary, CHUV Hospital (Switzerland)
Philippe Monnier, CHUV Hospital (Switzerland)
Georges A. Wagnieres, Swiss Federal Institute of Technology (Switzerland)


Published in SPIE Proceedings Vol. 2631:
Medical and Fiber Optic Sensors and Delivery Systems
Nathan I. Croitoru; Mitsunobu Miyagi; Guillermo Orellana; Annamaria Verga Scheggi; Henricus J. C. M. Sterenborg, Editor(s)

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