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Proceedings Paper

The role and mechanics of dendritic cells in tumor antigen acquisition and presentation following laser immunotherapy
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Paper Abstract

We extend our model of the antitumor immune response initiated by laser-immunotherapy treatment to more closely examine key steps in the immune response 1) tumor antigen acquisition by antigen-presenting dendritic cells (DCs) and 2) cytotoxic T cell (CTL) priming by lymphatic DCs. Specifically we explore the formation of DC-CTL complexes that lead to CTL priming. We find that the bias in the dissociation rate of the complex influences the outcome of treatment. In particular, a bias towards priming favors a rapid activated CTL response and the clearance of tumors.

Paper Details

Date Published: 19 February 2018
PDF: 8 pages
Proc. SPIE 10495, Biophotonics and Immune Responses XIII, 1049510 (19 February 2018); doi: 10.1117/12.2291694
Show Author Affiliations
Sean M. Laverty, Univ. of Central Oklahoma (United States)
Bryan A. Dawkins, Univ. of Central Oklahoma (United States)
Univ. of Tulsa (United States)
Wei R. Chen, Univ. of Central Oklahoma (United States)


Published in SPIE Proceedings Vol. 10495:
Biophotonics and Immune Responses XIII
Wei R. Chen, Editor(s)

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