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Proceedings Paper

Reactive oxygen species explicit dosimetry (ROSED) of a type 1 photosensitizer
Author(s): Yi Hong Ong; Michele M. Kim; Zheng Huang; Timothy C. Zhu
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Paper Abstract

Type I photodynamic therapy (PDT) is based on the use of photochemical reactions mediated through an interaction between a tumor-selective photosensitizer, photoexcitation with a specific wavelength of light, and production of reactive oxygen species (ROS). The goal of this study is to develop a model to calculate reactive oxygen species concentration ([ROS]rx) after Tookad®-mediated vascular PDT. Mice with radiation-induced fibrosarcoma (RIF) tumors were treated with different light fluence and fluence rate conditions. Explicit measurements of photosensitizer drug concentration were made via diffuse reflective absorption spectrum using a contact probe before and after PDT. Blood flow and tissue oxygen concentration over time were measured during PDT as a mean to validate the photochemical parameters for the ROSED calculation. Cure index was computed from the rate of tumor regrowth after treatment and was compared against three calculated dose metrics: total light fluence, PDT dose, reacted [ROS]rx. The tumor growth study demonstrates that [ROS]rx serves as a better dosimetric quantity for predicting treatment outcome, as a clinically relevant tumor growth endpoint.

Paper Details

Date Published: 12 February 2018
PDF: 10 pages
Proc. SPIE 10476, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVII, 104760V (12 February 2018); doi: 10.1117/12.2291385
Show Author Affiliations
Yi Hong Ong, The Univ. of Pennsylvania Health System (United States)
Univ. of Pennsylvania (United States)
Michele M. Kim, The Univ. of Pennsylvania Health System (United States)
Univ. of Pennsylvania (United States)
Zheng Huang, Fujian Normal Univ. (China)
Timothy C. Zhu, The Univ. of Pennsylvania Health System (United States)


Published in SPIE Proceedings Vol. 10476:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVII
David H. Kessel; Tayyaba Hasan, Editor(s)

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