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Resonantly enhanced coherent anti-Stokes Raman scattering
Author(s): Georgi I. Petrov; Vladislav V. Yakovlev
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Paper Abstract

Resonant coherent Raman spectroscopy based on electronic transitions is known for over 40 years to provide chemically specific information from molecules at micromolar concentrations. Unfortunately, live-cell and tissue imaging becomes challenging at shorter wavelength due to reduced threshold for cell damage and significantly increased light scattering. Thus, we evaluate resonant enhancement of vibrational transitions, which can be selectively excited to promote either stronger signal or to provide better selectivity of molecular excitation. We experimentally validate several new excitation schemes for coherent anti-Stokes Raman scattering imaging and discuss their pros and cons.

Paper Details

Date Published: 11 April 2018
PDF: 5 pages
Proc. SPIE 10498, Multiphoton Microscopy in the Biomedical Sciences XVIII, 104981R (11 April 2018); doi: 10.1117/12.2291335
Show Author Affiliations
Georgi I. Petrov, Texas A&M Univ. (United States)
Vladislav V. Yakovlev, Texas A&M Univ. (United States)


Published in SPIE Proceedings Vol. 10498:
Multiphoton Microscopy in the Biomedical Sciences XVIII
Ammasi Periasamy; Peter T. C. So; Karsten König; Xiaoliang S. Xie, Editor(s)

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