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Proceedings Paper

Detection of oral early cancerous lesion by using polarization-sensitive optical coherence tomography: mice model
Author(s): Hong-Yi Lee; Ping-Hsien Chen; Tzu-Han Lee; Kuo-Wei Chang; Wen-Chuan Kuo
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Paper Abstract

Oral cancer is the 11th most common cancer worldwide, especially in a male adult. The median age of death in oral cancer was 55 years, 10-20 years earlier than other cancers. Presently, oral cancer is often found in late stage, because the lesion is often flat in early stage and is difficult to diagnose under traditional white light imaging. The only definitive method for determining cancer is an invasive biopsy and then using histology examination. How to detect precancerous lesions or early malignant lesions is an important issue for improving prognosis of oral cancer. Optical coherence tomography (OCT) is a new optical tool for diagnosing early malignant lesions in the skin or gastrointestinal tract recently. Here we report a new method for detecting precancerous or early malignant oral lesions by using swept source polarization-sensitive optical coherence tomography (PS-OCT) with center-wavelength 1310 nm, bandwidth 110 nm and 100 kHz swept rate. We used all single-mode fiber design to detect the change of birefringence information in the epithelium structure. This system has an advantage that enables measurement of backscattered intensity and birefringence simultaneously with only one A-scan per transverse location. In preliminary result, we computed the slope of the every A-scan signal in tissue part using a linear-curve fitting in backscattered intensity and birefringence on the enface. In this research, we used an oral cancer mice model for observing the change of structure and birefringence properties in different stages of oral cancer mice. We presented the parametric enface imaging that can detect the early oral malignant lesions.

Paper Details

Date Published: 12 February 2018
PDF: 7 pages
Proc. SPIE 10484, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVI, 1048417 (12 February 2018); doi: 10.1117/12.2291314
Show Author Affiliations
Hong-Yi Lee, National Yang-Ming Univ. (Taiwan)
Ping-Hsien Chen, National Yang-Ming Univ. (Taiwan)
Taipei Veterans General Hospital (Taiwan)
Tzu-Han Lee, National Yang-Ming Univ. (Taiwan)
Kuo-Wei Chang, National Yang-Ming Univ. (Taiwan)
Wen-Chuan Kuo, National Yang-Ming Univ. (Taiwan)

Published in SPIE Proceedings Vol. 10484:
Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVI
Tuan Vo-Dinh; Anita Mahadevan-Jansen; Warren S. Grundfest, Editor(s)

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