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A novel small molecule mediate 18F-FDG excited fluorescence molecular imaging
Author(s): Zeyu Zhang; Hongbo Guo; Zhenhua Hu; Jie Tian
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Paper Abstract

Fluorescence molecular imaging (FMI) has been widely used in many medical fields with small molecule indocyanine green (ICG). However, low signal-background ratio and limited specificity to tumor remain big challenges for FMI. In this study, a novel excitation strategy is proposed on the basis of clinical approved ICG and 18F-FDG. A series of in vitro experiments are designed to reveal the mechanism and results show obvious decreasing of ICG fluorescence intensity with the increasing distance to excitation source. Meanwhile, the ICG fluorescence intensity is proportional to the activity of radiopharmaceutical. Results from different respects illustrate the promising of this proposed excitation strategy.

Paper Details

Date Published: 20 February 2018
PDF: 4 pages
Proc. SPIE 10497, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XVI, 1049705 (20 February 2018); doi: 10.1117/12.2291300
Show Author Affiliations
Zeyu Zhang, Xidian Univ. (China)
Institute of Automation (China)
Hongbo Guo, Institute of Automation (China)
Northwest Univ. (China)
Zhenhua Hu, Institute of Automation (China)
Jie Tian, Institute of Automation (China)

Published in SPIE Proceedings Vol. 10497:
Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XVI
Daniel L. Farkas; Dan V. Nicolau; Robert C. Leif, Editor(s)

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