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Proceedings Paper

OCT angiography reveals age-related differences in cerebral blood flow of anesthetized mice (Conference Presentation)

Paper Abstract

Normal aging is associated with various metabolic and vascular changes. In the brain, the aging leads to an impairment of vessel structure and function. Characterizing the cerebrovascular pathologies with age is of importance to elucidate the underlying mechanism of cognitive decline correlated with blood perfusion. Here, we examine the effect of aging on cerebral microcirculation up to a capillary flow scale. This study uses optical coherence tomography angiography (OCTA) to measure vessel tortuosity, red blood cell (RBC) speed in individual capillaries and capillary density in the sensory-motor cortex of 8 young (3-month-old) and 8 aged (16-month-old) mice under isoflurane anesthesia. The result shows that the surface arterial vessels are more tortuous and the capillary RBC speed is much higher in aged animals old compared with young ones. However, the capillary vessel density is significantly lowered in the aged group than the young group.

Paper Details

Date Published: 14 March 2018
Proc. SPIE 10493, Dynamics and Fluctuations in Biomedical Photonics XV, 104930J (14 March 2018); doi: 10.1117/12.2291096
Show Author Affiliations
Woo June Choi, Univ. of Washington (United States)
Yuandong Li, Univ. of Washington (United States)
Wei Wei, Univ. of Washington (United States)
Ruikang K. Wang, Univ. of Washington (United States)

Published in SPIE Proceedings Vol. 10493:
Dynamics and Fluctuations in Biomedical Photonics XV
Valery V. Tuchin; Kirill V. Larin; Martin J. Leahy; Ruikang K. Wang, Editor(s)

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