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Proceedings Paper

Quantitative phase imaging for enhanced assessment of optomechanical cancer cell properties
Author(s): Lena Kastl; Björn Kemper; Jürgen Schnekenburger
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Paper Abstract

Optical cell stretching provides label-free investigations of cells by measuring their biomechanical properties based on deformability determination in a fiber optical two-beam trap. However, the stretching forces in this two-beam laser trap depend on the optical properties of the investigated specimen. Therefore, we characterized in parallel four cancer cell lines with varying degree of differentiation utilizing quantitative phase imaging (QPI) and optical cell stretching. The QPI data allowed enhanced assessment of the mechanical cell properties measured with the optical cell stretcher and demonstrates the high potential of cell phenotyping when both techniques are combined.

Paper Details

Date Published: 23 February 2018
PDF: 5 pages
Proc. SPIE 10503, Quantitative Phase Imaging IV, 105032R (23 February 2018); doi: 10.1117/12.2290970
Show Author Affiliations
Lena Kastl, Univ. of Muenster (Germany)
Björn Kemper, Univ. of Muenster (Germany)
Jürgen Schnekenburger, Univ. of Muenster (Germany)

Published in SPIE Proceedings Vol. 10503:
Quantitative Phase Imaging IV
Gabriel Popescu; YongKeun Park, Editor(s)

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