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Proceedings Paper

Determination of optical properties, drug concentration, and tissue oxygenation in human pleural tissue before and after Photofrin-mediated photodynamic therapy
Author(s): Yi Hong Ong; Jonah Padawer-Curry; Jarod C. Finlay; Michele M. Kim; Andreea Dimofte; Keith Cengel; Timothy C. Zhu
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Paper Abstract

PDT efficacy depends on the concentration of photosensitizer, oxygen, and light delivery in patient tissues. In this study, we measure the in-vivo distribution of important dosimetric parameters, namely the tissue optical properties (absorption μa (λ) and scattering μs ’ (λ) coefficients), photofrin concentration (cphotofrin), blood oxygen saturation (%StO2), and total hemoglobin concentration (THC), before and after PDT. We characterize the inter- and intra-patient heterogeneity of these quantities and explore how these properties change as a result of PDT treatment. The result suggests the need for real-time dosimetry during PDT to optimize the treatment condition depending on the optical and physiological properties.

Paper Details

Date Published: 5 March 2018
PDF: 6 pages
Proc. SPIE 10476, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVII, 104760Y (5 March 2018); doi: 10.1117/12.2290727
Show Author Affiliations
Yi Hong Ong, The Univ. of Pennsylvania Health System (United States)
Univ. of Pennsylvania (United States)
Jonah Padawer-Curry, The Univ. of Pennsylvania Health System (United States)
Jarod C. Finlay, The Univ. of Pennsylvania Health System (United States)
Michele M. Kim, The Univ. of Pennsylvania Health System (United States)
Univ. of Pennsylvania (United States)
Andreea Dimofte, The Univ. of Pennsylvania Health System (United States)
Keith Cengel, The Univ. of Pennsylvania Health System (United States)
Timothy C. Zhu, The Univ. of Pennsylvania Health System (United States)


Published in SPIE Proceedings Vol. 10476:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVII
David H. Kessel; Tayyaba Hasan, Editor(s)

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