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Proceedings Paper

Photodynamic therapy-based combinations to overcome molecular, cellular and stromal resistance mechanisms in ovarian and pancreatic cancer (Conference Presentation)
Author(s): Imran Rizvi; Shubhankar Nath; Girgis Obaid; Huang-Chiao Huang; Mans Broekgaarden; Anne-Laure Bulin; Sriram R. Anbil; Utkan Demirci; David H. Kessel; Tayyaba Hasan

Paper Abstract

Drug resistance to conventional therapies remains a major cause of treatment failure, tumor recurrence and dismal survival rates for patients with advanced stage cancers. Photodynamic therapy (PDT) provides an opportunity to exploit photochemically-triggered death mechanisms via targeting of sub-cellular, cellular and stromal compartments to overcome treatment resistance in unresponsive populations of stubborn disease. The informed design of mechanism-based combinations is emerging as increasingly important to targeting resistance and improving the efficacy of conventional treatments, while minimizing toxicity. PDT has been shown to synergize with conventional agents and to overcome the evasion pathways that cause resistance. Increasing evidence shows that PDT-based combinations cooperate mechanistically with, and improve the therapeutic index of, traditional chemotherapies. These and other findings emphasize the importance of including PDT as part of comprehensive treatment plans for cancer, particularly in complex disease sites. Identifying effective combinations requires a multi-faceted approach that includes the development of bioengineered cancer models and corresponding image analysis tools. The presentation will focus on the molecular and phenotypic basis of verteporfin PDT-based enhancement of chemotherapeutic efficacy and predictability in complex 3D models and in vivo models, with a particular emphasis on ovarian and pancreatic cancer.

Paper Details

Date Published: 14 March 2018
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Proc. SPIE 10476, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVII, 1047604 (14 March 2018); doi: 10.1117/12.2290472
Show Author Affiliations
Imran Rizvi, Massachusetts General Hospital (United States)
Shubhankar Nath, Massachusetts General Hospital (United States)
Girgis Obaid, Massachusetts General Hospital (United States)
Huang-Chiao Huang, Massachusetts General Hospital (United States)
Mans Broekgaarden, Massachusetts General Hospital (United States)
Anne-Laure Bulin, Massachusetts General Hospital (United States)
Sriram R. Anbil, Massachusetts General Hospital (United States)
Utkan Demirci, Cancer Ctr., Stanford Univ. (United States)
David H. Kessel, Wayne State Univ. School of Medicine (United States)
Tayyaba Hasan, Massachusetts General Hospital (United States)


Published in SPIE Proceedings Vol. 10476:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVII
David H. Kessel; Tayyaba Hasan, Editor(s)

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