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Proceedings Paper

Simultaneous, noninvasive, in vivo, continuous monitoring of hematocrit, vascular volume, hemoglobin oxygen saturation, pulse rate and breathing rate in humans and other animal models using a single light source
Author(s): Paul Dent; Sai Han Tun; Seth Fillioe; Bin Deng; Josh Satalin; Gary Nieman; Kailyn Wilcox; Quinn Searles; Sri Narsipur; Charles M. Peterson; Jerry Goodisman; James Mostrom; Richard Steinmann; J. Chaiken
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Paper Abstract

We previously reported a new algorithm “PV[O]H” for continuous, noninvasive, in vivo monitoring of hematocrit changes in blood and have since shown its utility for monitoring in humans during 1) hemodialysis, 2) orthostatic perturbations and 3) during blood loss and fluid replacement in a rat model. We now show that the algorithm is sensitive to changes in hemoglobin oxygen saturation. We document the phenomenology of the effect and explain the effect using new results obtained from humans and rat models. The oxygen sensitivity derives from the differential absorption of autofluorescence originating in the static tissues by oxy and deoxy hemoglobin. Using this approach we show how to perform simultaneous, noninvasive, in vivo, continuous monitoring of hematocrit, vascular volume, hemoglobin oxygen saturation, pulse rate and breathing rate in mammals using a single light source. We suspect that monitoring of changes in this suite of vital signs can be provided with improved time response, sensitivity and precision compared to existing methodologies. Initial results also offer a more detailed glimpse into the systemic oxygen transport in the circulatory system of humans.

Paper Details

Date Published: 12 February 2018
PDF: 13 pages
Proc. SPIE 10484, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVI, 1048410 (12 February 2018); doi: 10.1117/12.2290231
Show Author Affiliations
Paul Dent, Syracuse Univ. (United States)
Sai Han Tun, Syracuse Univ. (United States)
Seth Fillioe, Syracuse Univ. (United States)
Bin Deng, Syracuse Univ. (United States)
Josh Satalin, SUNY Upstate Medical Univ. (United States)
Gary Nieman, SUNY Upstate Medical Univ. (United States)
Kailyn Wilcox, SUNY Upstate Medical Univ. (United States)
Quinn Searles, SUNY Upstate Medical Univ. (United States)
Sri Narsipur, SUNY Upstate Medical Univ. (United States)
Charles M. Peterson, Syracuse Univ. (United States)
Jerry Goodisman, Syracuse Univ. (United States)
James Mostrom, Crouse-Irving Memorial Hospital (United States)
Richard Steinmann, Crouse-Irving Memorial Hospital (United States)
J. Chaiken, Syracuse Univ. (United States)


Published in SPIE Proceedings Vol. 10484:
Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVI
Tuan Vo-Dinh; Anita Mahadevan-Jansen; Warren S. Grundfest, Editor(s)

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