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Proceedings Paper

Mueller tensor approach for nonlinear optics in turbid media
Author(s): James R. W. Ulcickas; Fengyuan Deng; Changqin Ding; Garth J. Simpson
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Paper Abstract

As plane-polarized light propagates through a turbid medium, scattering alters the phase and polarization differently in different locations. The corresponding depolarization of the beam complicates recovery of the rich information content contained within the polarization-dependence of second harmonic generation (SHG) microscopy. A theoretical framework connecting Jones and Stokes formalisms for describing optical polarization allows prediction of the polarization-dependent SHG produced from “ballistic”, but depolarized incident light. Measurements with collagen-rich tissue sections support the predictions of the framework. Partially polarized SHG produced from a depolarized source enabled recovery of local orientation distribution for collagen and local tensor information. Bridging the gap between SHG instigated by fully depolarized light and partially polarized light more common to practical turbid systems, a method for predicting local nonlinear optical susceptibility tensor elements was developed and applied to collagen in thick sections. Recovered values for the tensor element ratio ρ are in good agreement with previous results for thin tissue and literature reports.

Paper Details

Date Published: 23 February 2018
PDF: 10 pages
Proc. SPIE 10498, Multiphoton Microscopy in the Biomedical Sciences XVIII, 1049834 (23 February 2018); doi: 10.1117/12.2289999
Show Author Affiliations
James R. W. Ulcickas, Purdue Univ. (United States)
Fengyuan Deng, Purdue Univ. (United States)
Changqin Ding, Purdue Univ. (United States)
Garth J. Simpson, Purdue Univ. (United States)

Published in SPIE Proceedings Vol. 10498:
Multiphoton Microscopy in the Biomedical Sciences XVIII
Ammasi Periasamy; Peter T. C. So; Karsten König; Xiaoliang S. Xie, Editor(s)

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