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Proceedings Paper

Liquid crystal nanoparticles for delivery of photosensitizers for photodynamic therapy
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Paper Abstract

The main principle of photodynamic therapy (PDT) is to kill malignant cells by generation of reactive oxygen species (ROS). PDT appeared highly effective when ROS can be produced in subcellular location such as plasma membrane. The plasma membrane maintains the structural integrity of the cell and regulates multiple important cellular processes, such as endocytosis, trafficking, and apoptotic pathways, could be one of the best points to kill the cancer cells. Previously, we have developed a plasma membrane-targeted liquid crystal nanoparticle (LCNP) formulation that can be loaded with dyes or drugs. Here we highlight the utility of this LCNP for membrane targeted delivery and imaging for a photosensitizer (PS) for PDT applications.

Paper Details

Date Published: 23 February 2018
PDF: 7 pages
Proc. SPIE 10507, Colloidal Nanoparticles for Biomedical Applications XIII, 1050711 (23 February 2018); doi: 10.1117/12.2289970
Show Author Affiliations
Okhil K. Nag, U.S. Naval Research Lab. (United States)
Jawad Naciri, U.S. Naval Research Lab. (United States)
James B. Delehanty, U.S. Naval Research Lab. (United States)


Published in SPIE Proceedings Vol. 10507:
Colloidal Nanoparticles for Biomedical Applications XIII
Marek Osiński; Wolfgang J. Parak; Xing-Jie Liang, Editor(s)

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