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Proceedings Paper

Multispectral photoacoustic characterization of ICG and porcine blood using an LED-based photoacoustic imaging system
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Paper Abstract

Photoacoustic imaging is a hybrid biomedical imaging modality that has emerged over the last decade. In photoacoustic imaging, pulsed-light absorbed by the target emits ultrasound that can be detected using a conventional ultrasound array. This ultrasound data can be used to reconstruct the location and spatial details of the intrinsic/extrinsic light absorbers in the tissue. Recently we reported on the development of a multi-wavelength high frame-rate LED-based photoacoustic/ultrasound imaging system (AcousticX). In this work, we photoacoustically characterize the absorption spectrum of ICG and porcine blood using LED arrays with multiple wavelengths (405, 420, 470, 520, 620, 660, 690, 750, 810, 850, 925, 980 nm). Measurements were performed in a simple reflection mode configuration in which LED arrays where fixed on both sides of the linear array ultrasound probe. Phantom used consisted of micro-test tubes filled with ICG and porcine blood, which were placed in a tank filled with water. The photoacoustic spectrum obtained from our measurements matches well with the reference absorption spectrum. These results demonstrate the potential capability of our system in performing clinical/pre-clinical multispectral photoacoustic imaging.

Paper Details

Date Published: 19 February 2018
PDF: 5 pages
Proc. SPIE 10494, Photons Plus Ultrasound: Imaging and Sensing 2018, 104943O (19 February 2018); doi: 10.1117/12.2289950
Show Author Affiliations
Yusuke Shigeta, PreXion Corp. (Japan)
Naoto Sato, PreXion Corp. (Japan)
Mithun Kuniyil Ajith Singh, PreXion Corp. (Netherlands)
Toshitaka Agano, PreXion Corp. (Japan)

Published in SPIE Proceedings Vol. 10494:
Photons Plus Ultrasound: Imaging and Sensing 2018
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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