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Brillouin light scattering spectroscopy for tissue engineering application
Author(s): Dana Akilbekova; Talgat Yakupov; Vyacheslav Ogay; Bauyrzhan Umbayev; Vladislav V. Yakovlev; Zhandos N. Utegulov
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Paper Abstract

Biomechanical properties of mammalian bones, such as strength, toughness and plasticity, are essential for understanding how microscopic scale mechanical features can link to macroscale bones’ strength and fracture resistance. We employ Brillouin light scattering (BLS) micro-spectroscopy for local assessment of elastic properties of bones under compression and the efficacy of the tissue engineering approach based on heparin-conjugated fibrin (HCF) hydrogels, bone morphogenic proteins (BMPs) and osteogenic stem cells in the regeneration of the bone tissues. BLS is noninvasive and label-free imaging modality for probing mechanical properties of hard tissues that can give information on structure-function properties of normal and pathological tissues. Results showed that HCF gels containing combination of all factors had the best effect with complete defect regeneration at week 9 and that the bones with fully consolidated fractures have higher values of elastic moduli compared to the bones with defects.

Paper Details

Date Published: 19 February 2018
PDF: 7 pages
Proc. SPIE 10496, Optical Elastography and Tissue Biomechanics V, 104961I (19 February 2018); doi: 10.1117/12.2289923
Show Author Affiliations
Dana Akilbekova, Nazarbayev Univ. (Kazakhstan)
Talgat Yakupov, Nazarbayev Univ. (Kazakhstan)
Vyacheslav Ogay, National Ctr. for Biotechnology (Kazakhstan)
Bauyrzhan Umbayev, Nazarbayev Univ. (Kazakhstan)
Vladislav V. Yakovlev, Texas A&M Univ. (United States)
Zhandos N. Utegulov, Nazarbayev Univ. (Kazakhstan)


Published in SPIE Proceedings Vol. 10496:
Optical Elastography and Tissue Biomechanics V
Kirill V. Larin; David D. Sampson, Editor(s)

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