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Proceedings Paper

Behavior of HepG2 liver cancer cells using microfluidic-microscopy: a preliminary study
Author(s): Hande Karamahmutoglu; Metin Çetin; Tamer Yağcı; Meltem Elitaş
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Paper Abstract

Hepatocellular carcinoma is one of the most common types of liver cancer causing death all over the world. Although early-stage liver cancer can sometimes be treated with partial hepatectomy, liver transplantation, ablation, and embolization, sorafenib treatment is the only approved systemic therapy for advanced HCC. The aim of this research is to develop tools and methods to understand the individuality of hepatocellular carcinoma. Microfluidic cell-culture platform has been developed to observe behavior of single-cells; fluorescence microscopy has been implemented to investigate phenotypic changes of cells. Our preliminary data proved high-level heterogeneity of hepatocellular carcinoma while verifying limited growth of liver cancer cell lines on the silicon wafer.

Paper Details

Date Published: 19 February 2018
PDF: 5 pages
Proc. SPIE 10491, Microfluidics, BioMEMS, and Medical Microsystems XVI, 104910Y (19 February 2018); doi: 10.1117/12.2289863
Show Author Affiliations
Hande Karamahmutoglu, Sabanci Univ. (Turkey)
Metin Çetin, Gebze Teknik Üniv. (Turkey)
Tamer Yağcı, Gebze Teknik Üniv. (Turkey)
Meltem Elitaş, Sabanci Univ. (Turkey)

Published in SPIE Proceedings Vol. 10491:
Microfluidics, BioMEMS, and Medical Microsystems XVI
Bonnie L. Gray; Holger Becker, Editor(s)

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