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Proceedings Paper

Development of a diamond waveguide sensor for sensitive protein analysis using IR quantum cascade lasers
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Paper Abstract

Microfabricated diamond waveguides, between 5 and 20 μm thick, manufactured by chemical vapor deposition of diamond, followed by standard lithographic techniques and inductively coupled plasma etching of diamond, are used as bio-chemical sensors in the mid infrared domain: 5-11 μm. Infrared light, emitted from a broadly tunable quantum cascade laser with a wavelength resolution smaller than 20 nm, is coupled through the diamond waveguides for attenuated total reflection spectroscopy. The expected advantages of these waveguides are a high sensitivity due to the high number of internal reflections along the propagation direction, a high transmittance in the mid-IR domain, the bio-compatibility of diamond and the possibility of functionalizing the surface layer. The sensor will be used for analyzing different forms of proteins such as α-synuclein which is relevant in understanding the mechanism behind Parkinson's disease. The fabrication process of the waveguide, its characteristics and several geometries are introduced. The optical setup of the biosensor is described and our first measurements on two analytes to demonstrate the principle of the sensing method will be presented. Future use of this sensor includes the functionalization of the diamond waveguide sensor surface to be able to fish out alpha-synuclein from cerebrospinal fluid.

Paper Details

Date Published: 22 February 2018
PDF: 10 pages
Proc. SPIE 10539, Photonic Instrumentation Engineering V, 105390F (22 February 2018); doi: 10.1117/12.2289844
Show Author Affiliations
P. Piron, Uppsala Univ. (Sweden)
E. Vargas Catalan, Uppsala Univ. (Sweden)
J. Haas, Univ. Ulm (Germany)
L. Österlund, Uppsala Univ. (Sweden)
Molecular Fingerprint Sweden AB (Sweden)
F. Nikolajeff, Uppsala Univ. (Sweden)
Molecular Fingerprint Sweden AB (Sweden)
P. O. Andersson, Uppsala Univ. (Sweden)
Molecular Fingerprint Sweden AB (Sweden)
J. Bergström, Uppsala Univ. (Sweden)
B. Mizaikoff, Univ. Ulm (Germany)
M. Karlsson, Uppsala Univ. (Sweden)
Molecular Fingerprint Sweden AB (Sweden)

Published in SPIE Proceedings Vol. 10539:
Photonic Instrumentation Engineering V
Yakov G. Soskind, Editor(s)

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